After 10 years in use without systematic supportive treatment, peri-implant lesions is a common clinical entity adjacent to titanium implants.

Individuals with a history of periodontitis and individuals who smoke are more likely to develop peri-implant lesions.

A history of periodontitis seems to be related to implant loss.

At implant sites studied, few bacteria differed by whether subjects were dentate or not or by implant status.

The use of a repeated local antibiotic as an adjunct to the mechanical treatment of peri-implantitis lesions demonstrated improvements in probing depths that were significantly different from controls and were sustained for 6 months. The adjunctive use of minocycline microspheres is beneficial in the treatment of peri-implant lesions, but the treatment may have to be repeated.