Muscle biopsies from two female patients with systemic sclerosis (SS) and an inflammatory myopathy were studied ultrastructurally in relation to the possible presence of apoptosis in skeletal muscle fibers. Undergoing apoptosis showed characteristic morphological features of this process, including chromatin aggregation as well as nuclear and sarcoplasmic partition into membrane bound-vacuoles (apoptotic bodies) which contained autophagosomes, mitochondria, isolated myofilaments and nuclear material. Vacuoles exhibited different diameters and were covered by single membranes, appearing beneath basement membrane. Apoptosis occurred in some fiber segments as in necrosis or included whole atrophied fibers. These results indicate that apoptosis coexists with necrosis in the inflammatory myopathy of SS.
Liver metastases from colon adenocarcinoma cells exhibited features of primary tumor site such as microvilli with filamentous cores and long rootlets, glycocalyceal bodies, and classical desmosomes. Nevertheless, some cell surfaces showed scarce and short microvilli. Attenuated and imperfect desmosomes were also seen as well as swelling of rough endoplasmic reticulum, Golgi apparatus cisternae and mitochondria with electron-dense granules and scarce cristae, and the proliferation of lysosomal myelin-like figures and multivesicular bodies. In some areas, neoplastic cell entered into contact with hepatocytes and macrophages. It is concluded that in liver the invasive phenotype produced metastatic foci with cellular distinctive aspects, several of them different from the primary tumor.
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