The versatile multifunctional hitherto unreported 2,6-bis-[3-oxo-3-propanenitrile-2-(N,Ndimethylamino)methylene]pyridine 3 was prepared by the reaction of pyridine-2,6-bis-(3-oxo-3-propanenitrile) 2 with dimethylformamide-dimethylacetal (DMF-DMA). Several new pyrazole, isoxazole, pyrimidine, pyrazolopyrimidine, triazolopyrimidine and imidazopyrimidine derivatives have been synthesized by the reactions of 2,6-bis[3-oxo-3-propanenitrile-2-(N,Ndimethylamino)methylene]pyridine 3 with several nitrogen binucleophiles.
Synthesis and Antitumor Activity of New Polysubstituted Thiophenes and 1,3,4-Thiadiazoles Incorporating 2,6-Pyridine Moieties. -Several new polysubstituted thiophene and thiadiazole derivatives incorporating a 2,6-pyridine moiety are efficiently synthesized using hitherto not reported bis(3-oxopropanethioamide) (III) as key building block. Some of the prepared compounds show better anticancer activities than the reference drug doxorubicin. -(ALI*, K. A.; ABDALGHFAR, H. S.; MAHMOUD, K.; RAGAB, E. A.; J.
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