Residues of amitraz in the tissues of steers slaughtered 24 and 48 hours after dipping in Taktic � (0.025% amitraz) were <0.02 mg kg-1. Milk and butter residues from cows dipped in Taktic reached a maximum of 0.01 and 0.1 7 mg kg-1, respectively, 6 hours after treatment, declining to 0.01 mg kg-1 2 days after treatment. Residues in butter collected during a 3-week period from a local dairy products factory were less than 0.01 mg kg-1. Some of the herds supplying the factory were dipped in Taktic.
SummaryA European collaborative study, in which 16 laboratories participated, was carried out to assess the performance of the European Pharmacopoeia (EP) monograph methods for anticoagulant activities (anti-Xa and anti-IIa assays) of low molecular mass (EMM) heparin and to assess the suitability of six candidate materials as the EP working standard for LMM heparin. There was good interlaboratory agreement for both types of assays as indicated by most gcv’s being less than 10%, indicating acceptable performance of the EP assay methods. All the candidate preparations gave dose-response curves parallel to the 1st International Standard for Low Molecular Weight heparin and to each other. All preparations, possibly with the exception of E and F, gave similar performance as measured by interlaboratory agreement and would be suitable as working standards. Based on these data, preparations A, B, C and D have been established by the EP as official EP Biological Reference Preparations and they will be issued as successive batches.
Three experiments were conducted to determine the concentrations of residues of chlordimeform in tissues and milk of cattle after spray application to control cattle tick. Subcutaneous fat, sampled by biopsy from animals sprayed with 0.45 per cent (w/v), 0.15 per cent and 0.05 per cent chlordimeform (buffered) contained maximum residues of chlordimeform (2.88 mg kg-1, 0.46 mg kg-1 and 0.1 5 mg kg-1 respectively) one day after treatment. The half life for the rate of disappearance of these residues was independent of the initial residue level and was calculated as 2.46 days. Sampling of six tissues, 24 hours after spraying with chlordimeform (buffered) showed that chlordimeform was found mainly in fat. Smaller concentrations were found in kidney, muscle and liver tissue. Concentrations of 0.45 per cent, 0.15 per cent and 0.05 per cent chlordimeform (buffered) produced residues of 1.42 mg kg-1, 0.28 mg kg-1 and 0.03 mg kg-1 respectively in the whole milk of lactating cows. A half life of 0.45 day was calculated for the rate of disappearance of chlordimeform from the milk.
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