Residues of amitraz in the tissues, milk and butter of cattle dipped in Taktic

Abstract

Residues of amitraz in the tissues of steers slaughtered 24 and 48 hours after dipping in Taktic � (0.025% amitraz) were <0.02 mg kg-1. Milk and butter residues from cows dipped in Taktic reached a maximum of 0.01 and 0.1 7 mg kg-1, respectively, 6 hours after treatment, declining to 0.01 mg kg-1 2 days after treatment. Residues in butter collected during a 3-week period from a local dairy products factory were less than 0.01 mg kg-1. Some of the herds supplying the factory were dipped in Taktic.

Disposition Kinetics of Amitraz in Lactating Does

“…Furthermore, previous studies conducted in rats, beagles, and pigs following dermal treatment of 14 C-amitraz showed that the washing of treated skin with soap and water 10–12 h after application resulted in the removal of 60–90% of the applied amitraz, with only 3% and 1.4% of the drug remaining on the skin after 24 h and after 5 days, respectively. Hence, it is presumed that a portion of the applied drug that remained on the skin and absorbed into the systemic circulation might have attributed to its detection in the blood until 168 h. Following dermal administration, 90% of the drug was eliminated in the urine and feces, with very low concentration (less than 0.05 ppm) found in most of the tissues [ 16 , 30 ]. Since recovery and tissue residual concentrations were not carried out in the present study, the proportion excreted through urine, feces, and the amount retained in the tissues could not be quantified.…”

“…These findings were consistent with the studies conducted in a cow following oral administration of amitraz in capsules [ 16 ]. Moreover, amitraz was detected at a concentration of 0.01 mg/kg in the milk of cattle dipped with Taktic ® (0.025 per cent of amitraz) [ 30 ].…”