In order to investigate the influence of the unit junction on the micromixer performance, a repetitive structure micromixer with a total length of 12.3 mm was proposed. This micromixer consists of a T-shape inlet channel and six cubic mixing units, as well as junctions between them. Numerical simulations show that, when the junctions are all located at the geometric center of the cubic mixing unit, the outlet mixing index is 72.12%. At the same flow velocity, the best mixing index achieved 97.15% and was increased by 34.68% when the junctions were located at different corners of the cubic mixing unit. The improvement in the mixing index illustrated that the non-equilibrium vortexes generated by changing the junction location to utilize the restricted diffusion by the mixing unit’s side wall could promote mixing. Visual tests of the micromixer chip prepared by 3D printing were consistent with the simulation results, also indicating that the junction location had a significant influence on the mixer’s performance. This article provides a new idea for optimizing the structural design and improving the performance of micromixers.
When the free end of a microcantilever is modified by a genetic probe, this sensor can be used for a wider range of applications, such as for chemical analysis, biological testing, pharmaceutical screening, and environmental monitoring. In this paper, to clarify the preparation and detection process of a microcantilever sensor with genetic probe modification, the core procedures, such as probe immobilization, complementary hybridization, and signal extraction and processing, are combined and compared. Then, to reveal the microcantilever’s detection mechanism and analysis, the influencing factors of testing results, the theoretical research, including the deflection principle, the establishment and verification of a detection model, as well as environmental influencing factors are summarized. Next, to demonstrate the application results of the genetic-probe-modified sensors, based on the classification of detection targets, the application status of other substances except nucleic acid, virus, bacteria and cells is not introduced. Finally, by enumerating the application results of a genetic-probe-modified microcantilever combined with a microfluidic chip, the future development direction of this technology is surveyed. It is hoped that this review will contribute to the future design of a genetic-probe-modified microcantilever, with further exploration of the sensitive mechanism, optimization of the design and processing methods, expansion of the application fields, and promotion of practical application.
In this paper, a sequence of passive micromixers with spiral patterns on the side wall of cylindrical chambers are designed, optimized, prepared and tested. The simulation studies show that the vortex magnitude and continuity in the mixing chamber are the most important factors to determine mixing performance, while the inlet position and structural parameters are secondary influences on their performance. According to the above principles, the performance of a micromixer with a continuous sidewall spiral finally wins out. The total mixing length is only 14 mm, but when Re = 5, the mixing index can reach 99.81%. The multi-view visual tests of these mixer chips prepared by 3D printing are consistent with the simulation results. This paper provides a new idea for optimizing the micromixer with spiral patterns on the side wall and the problems of floor area and pressure loss are significantly improved compared to the conventional spiral structure.
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