Objective:To examine the occurrence frequency of auto-antibodies and autoimmune diseases in patients with chronic hepatitis B or C.Methods:A total of 67 patients diagnosed with chronic hepatitis B and 77 patients diagnosed with chronic hepatitis C infection based on HBs Ag, Anti HCV, HBe Ag, Anti HBe Ag, HBV DNA, HCV RNA, liver ultrasound, and liver biopsy results as well as 48 healthy individuals were included in this study. ANA, anti dsDNA, anti LKM, Anti-SMA, AMA, C-ANCA, P-ANCA, anti-SSA, anti-SSB, anti-Scl-70, anti Jo-1, anti-U1snRNP, anti-centromere, anti-Jo-1, anti tpo, and anti tg were studied in all individuals in each study group.Results:ANA positivity was detected in 8 (12%), 15 (19%) and 2 (4%) individuals in HBV, HCV and control groups, respectively. The difference between the groups was significant (P=0.04). Similarly, anti Tg was positive in one subject in HBV group, in 6 subjects (7%) in HCV group, and in one subject among controls, the difference being significant (P=0.04). There were no significant differences between the study groups in the frequency of other auto-antibodies.Conclusion:Similar to studies involving patients who received interferon and/or antiviral agents, an increased frequency of auto-antibodies was also detected in our patient group consisting of interferon and anti-viral naive subjects. The increase in the frequency of auto-antibodies reached statistical significance among individuals with HCV infection. Thus, pre-treatment assessment of auto-antibodies in newly diagnosed cases of chronic hepatitis B or hepatitis C infection may provide beneficial information on the future occurrence of auto-immune responses in these patients.

Objective: Cystic echinococcosis (CE) is a globally prevalent zoonotic disease. Methods: Demographic, clinical, laboratory, and follow-up data of patients between May 2009 and 2015 were retrospectively analyzed by screening data from a hospital automation system. Results: A total of 238 (females, n=139 and males, n=99) patients with a mean age of 40.6±20.58 years were included. Less than half (40.8%) of the patients were living in the countryside. Hepatic involvement of CE was most frequently (72.2%) seen. A majority (75.6%) of the patients were symptomatic, but abdominal pain was the most frequently seen symptom. For diagnosis, in all patients, imaging modalities were used, while in 66% of the patients, serological methods were also employed. The patients received both medical and surgical treatments (78.5%, n=187), only surgical treatment (10.5%, n=25), or only medical treatment (8.8%, n=21). Surgical treatment was performed for patients with hepatic (n=139/176, 80.6%), pulmonary (n=78/94, 82.9%), splenic (n=7/9; 77.7%), and mesenteric (n=6/7, 85.1%) cysts, and patients cases with brain, bone, muscle, omentum, bladder, and adrenal cysts had undergone surgical intervention. Conclusion: Publication of regional data is important in terms of epidemiological considerations and may aid in the formulation of standard treatment approaches. En sık tutulan organ karaciğer (%72,2) idi. Hastaların %75,6'sı semptomatik olup en sık görülen semptom karın ağrısı idi. Tanıda tüm hastalarda görüntüleme yöntemine başvurulurken, %66' sında serolojik yöntem de kullanılmıştı. Hastaların % 78,5'i (n=187) hem medikal hem cerrahi tedavi, %10,5'i (n=25) yalnız cerrahi tedavi, %8,8'i (n=21) ise yalnız medikal tedavi almıştı. Karaciğer tutulumu saptanan 173 hastanın %80,6'sına (n=139), akciğer tutulumu saptanan 94 hastanın %82,9'una (n=78), dalakta tutulum saptanan 9 hastanın %77,7' sine (n=7), mesenterde kist saptanan 7 hastanın %85,1'ine (n=6); beyin, kemik, kas, omentum, mesane ve sürrenalde kist saptananların ise tümüne cerrahi uygulandığı tespit edildi. Sonuç: Bölgesel verilerin yayınlanması, epidemiyolojik açıdan önem taşıdığı gibi standart tedavi algoritmalarının oluşturulmasına yardımcı olabilir.

No abstract

ÖZMetoklopramid çeşitli gastrointestinal semptomların tedavisinde kullanılan dopamin reseptör antagonisti olan bir ilaçtır. Akut distonik reaksiyonlar genellikle bukkolingual, tortikollis, okülojirik ve/veya opistotonik şekillerde olmaktadır. Okülojirik kriz, metoklopramidin nadir rastlanan bir yan etkisidir.Bu makalede, tedavi dozunda metoklopramid kullanmakta iken, okülojirik kriz gelişen bir olgu sunulmuştur. Akut distoni ile acil servise başvuran hastalarda, sık kullanılan bir antiemetik olan metoklopramidin yan etkisinin olabileceği unutulmamalı ve bu durumda, hastalarda mutlaka ilaç kullanım öyküsü sorgulanmalıdır.Anahtar Kelimeler: Metoklopramid; okülojirik kriz; yan etki. ABSTRACTMetoclopramide is a dopamine receptor antagonist drug that has been used for treatment of a variety of gastrointestinal symptoms. Acute dystonic reactions usually present themselves as buccolingual, torticollis, oculogyric, and/or opisthotonic forms. Oculogyriccrisis, are rare side effects of metoclopramide. In this article, a case was presented with oculogyric crisis while using therapeutic dose of metoclopramide. It should be kept in mind that metoclopramide, a commonly used antie¬metic in patients referred to the emergency service with acute dystonia, might have side effects. In this setting, a history of medication use must be examined from the patients, absolutely.

Araştırma

Objective: In this study, we aim to evaluate and determine the distribution and frequency of infectious diseases and the hospitalization rates of in-and out-patients aged 65 or above applying to the emergency department. Methods: All the patients over 65 were included in this retrospective study. Patients' records were scanned for computer-assisted patient record system. The diagnosis were made according to International Classification of Diseases (ICD-10) system. Data were analyzed by using Statistical Package for the Social Sciences (SPSS) 20.0 (SPSS Inc., Chicago, IL, USA). Results: During the study period, of the total of 271 561 admissions to the emergency department, 27 516 (10.1%) patients were over 65 years old. The number of patients in this age group diagnosed according to ICD-10 coding of infectious diseases were 6802 (24.7%) and 48% were female while 52% were male. The most common infectious diseases responsible for admissions were upper respiratory tract infection (41.9%), lower respiratory tract infection (33.7%), urinary tract infection (11.1%), and acute gastroenteritis (8.5%). Of these patients, 11.2% were hospitalized, 88% were discharged from the hospital with intervention and treatment, 0.7% were referred to an advanced health institution, and 0.1% died. Conclusions:The percentage of elderly people applying to the emergency department is increasing. Advanced age and underlying diseases are predisposing factors for infection. Taking into account that laboratory and clinical findings in geriatric patients may be different than young adults, we think closer attention must be paid to this patient group. Klimik Dergisi 2015; 28(2): 76-9.

No abstract

Anthrax is a zoonotic infectious disease caused by B.anthracis. Declining with each passing day in our country is still an endemic disease. Cutaneous anthrax-(CA) is the most common form and consists of approximately 95% of all cases of anthrax. In this study, we report and discuss with literature 4 skin anthrax diagnosed patients who admitted to emergency service with complaints of no pain and black colored wound on their hands in the same family members. (Eurasian J Emerg Med 2016; 15: 54-5)