Absolute linkage between the gene, on chromosome 19, for the calcium release channel (CRC) of the sarcoplasmic reticulum in skeletal muscle and malignant hyperthermia (MH) has been reported by other workers. In the present study of three Swedish Families informative with respect to this linkage relationship, definite recombinants were found in two families. We conclude that mutations in other genes than the CRC gene can cause the clinical picture of MH. Accordingly, MH appears to be genetically heterogeneous.
HALJGE, J . Cr. and R. NICOLAYSES. The seruni cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaem ic rats. Acta physiol. scad. 1959. 45, 26--30. --With the aid of the method of HAUGE and NICOLAYSEN the serum cholcsterol depressive effect of various samples of highly unsaturated fatty acids or oils W~S studied. Linolenic acid had a Btronger depressive effect than linoleic acid, and the polyunsaturated fatty acids of cod liver oil seemed to have an even stronger effect, since the effect of whole cod liver oil was a t least equal to that of linolenir acid.
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