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Background: Triple-negative breast cancer (TNBC) has none of the targeted treatment choices due to its distinct biological property, making this subtype a unique disease. In this study, we evaluated the impact of obesity on clinical outcomes of TNBC. Methods: The data of breast cancer patients admitted to our department were collected. TNBC was defined as lack of estrogen receptor (ER), progesterone receptor (PR) and HER-2. The body mass index (BMI) of 112 TNBC patients was calculated with weight at the time of diagnosis and height. The patients were classified into groups with a BMI of < 25 (normal/underweight), 25-29.9 (overweight) or ≥ 30 (obese). After a mean follow-up of 23.2 ± 15.5 months, there were 12 recurrences (10.71%) and 6 deaths (5.35%). Disease-free survival (DFS) and overall survival (OS) were assessed. Results: The survival analyses of all the patients did not demonstrate any differences in OS or DFS in obese as compared to non-obese patients. However, we showed that obesity was associated with a poorer OS for postmenopausal TNBC patients (p < 0.05). Conclusion: Obesity is related to a poorer OS in postmenopausal TNBC patients. Due to the heterogeneous disease profile of TNBC, larger randomized studies will be needed to clarify the exact role of obesity in TNBC.

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Diabetic foot infections are an important cause of morbidity. In humans, Fusarium causes external infections. A male obese patient at the age of 56 who had been getting treatment in various clinics due to ulceration and lymphedema. Treatment started with tigecycline 50 mg vial 2x1. Alcaligenes faecalis and Proteus vulgaris reproduced. Tigecycline treatment was stopped on the 4th day and piperacillin/tazobactam 4,5 gr vial 3x1 and liposomal amphotericin B 3 mg/kg/day were initiated. In direct microscopic examination, hypes were seen and Fusarium spp. reproduction was detected. Liposomal amphotericin treatment was stopped on the 15th day and voriconazole 200 mg tb po 2x1 was initiated. At the end of one month, the lesions were regressed entirely. It should not be forgotten that despite its scarcity, fungus factors might give rise to diabetic foot infections and patients should be evaluated in terms of fungus infections. J Microbiol Infect Dis 2017; 7(1): 42-45

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