A new route to the synthesis of 4-chloro-5-alkyl-phthalonitrile derivatives was shown by the displacement reaction of 4,5-dichloro-phthalonitrile and diethylmalonate, a CH -acidic precursor, in the presence of K 2 CO 3. Cyclotetramerization of 1-chloro-3,4-dicyano-6-(1,1-dicarbethoxy-methyl)benzene and the metal salt without any solvent gave the corresponding metallophthalocyanines ( M = Co , Cu or Pd ). Transesterification occurred when the reaction was carried out in hexanol in the presence of DBU to obtain the metal-free derivative. Treatment of 1-chloro-3,4-dicyano-6-(1,1-dicarbethoxy-methyl)benzene with sodium ethoxide at ambient temperature and further acidification resulted in 2,9,16,23-tetra(carboxymethyl)-3,10,17,24-tetrachloro-phthalocyaninatopalladium(II) with partial decarboxylation. Its electronic spectrum in aqueous solution indicated no appreciable change over a pH range from 7 to 12.
A selective and highly sensitive electrochemical pesticide sensor (EPS) was constructed for the first time in this study with a new electrode modification technique, called "click electrochemistry" (CEC). With CEC technique, a cobalt phthalocyanine bearing alkyne terminal substituents (TA-CoPc) was electrochemically bonded to the azide groups of poly 4-azidoaniline (ANI-N 3 ) which was previously electropolymerized on a glassy carbon electrode and consequently a modified electrode (GCE/PANI-N 3 /TA-CoPc was constructed. Constructed EPS electrode was characterized with electrochemical, electrochemical impedance spectroscopy (EIS) and UV-Vis spectroscopy techniques. Voltammetric analysis of the electrode indicated that EPS electrode gave aniline and CoPc based redox couples in aqueous solution, which are the fundamental requirements of a functional material for the electrochemical sensor applications. Thus this electrode was tested as a possible EPS with SWV, EIS and double potential step chronocoulometry (DPSCC) techniques. EPS electrode gave different redox peaks during interaction with different pesticides which indicated selectivity for especially eserine, parathion, carbaryl, and carbofuran pesticides. EPS electrode was introduced as an excellent selective and reproducible electrochemical pesticide sensor.
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