The present study aimed to investigate the possible ameliorative effect of crude water extract of Morus alba leaves on developmental defects of cerebral cortex of rat pups maternally subjected to diabetes and/or aluminum (Al) intoxication. One hundred and forty fertile male and virgin female albino rats were used for the experimentation. The pregnant rats were arranged into seven groups. The study included five integrated approaches and all proved that treatment with Morus alba leaves extract led to a marked amelioration for the developmental defects caused by either diabetes or Al intoxication at all levels of the study. At the ultrastructural level, the cerebral cortex of the latter exhibited massive cytological alterations of Purkinje cells (PC) and Karyolysis of chromatin material. The cytoplasm appeared translucent and enclosed by either fragmented or vesiculated RER. Mitochondria appeared electron-dense with ill-differentiated cristae. Cytoplasmic vacuoles were detected. However, pups of mothers received Morus alba extract and subjected to Al intoxication and/or diabetes showed partial amelioration of cytological structure of PC. The nuclear envelope was regularly arranged and enclosed by normal euchromatin. The cytoplasmic organelles were rearranged and approximately restored their pattern. It can therefore be concluded that leaves extract of Morus alba has marked ameliorative effects against developmental defects of cerebral cortex in pups of diabetic and Al intoxicated pregnant albino rats.
Many studies have focused on the aging related hypertrophy and prostate injuries. The use of natural product to prevent the prostate tissues degradation are of particular concern. The study's aim was to determine the biological significance of whey supplementation in optimizing aging-related changes in the structure and function of prostate of aged rats. Male Wistar albino rats aged 8 and 30-months were categorized into two main groups with or without whey supplementation (n=8). After two months of oral whey supplementation (2 ml, twice doses/day), the rats were euthanized, blood was collected and serum was separated for assessments of serum hormonal levels of testosterone and tri-and tetra-iodothyronin. The prostate was dissected and processed for histological, immunohistochemical and transmission electron microscopy. The studies showed that whey supplementation alleviated the shrieked and atrophy of prostate acini as well as hyperplasia of their lining epithelium. Whey supplementation also decreased expression of the caspase 3 and prostate specific antigen (PSA) immunohistochemistry. This was influenced by increased the immune reaction of proliferating cell nuclear antigen (PCNA).This were also associated with improved the serum hormonal levels of testosterone and triodo-and tetra-iodothyronine. Finally the author finally concluded that whey supplementation improved properties of aged properties and reduced hyperplasia, inflammatory lesions and collagenous infiltration. Increased testosterone and thyroid hormonal levels were also found.
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