Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats

El-Sayyed, Hassan; Badawy, Gamal M.; El-Nabi, Sobhy Hassab; El-Elaimy, Ibrahim A.; Shehari, Eman Al

doi:10.1016/s2221-1691(15)30349-x

Cited by 5 publications

(5 citation statements)

References 49 publications

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“…The leaves of the mulberry tree are known worldwide as sources of phytotherapeutics, which have been used for the treatment of conditions related to diabetes and been recorded based on clinical trials or the use of animal models (Banu et al, ; El‐Sayyed, Badawy, Elnabi, El‐Elaimy, & Shehari, ; Zhang et al, ). A large number of animal and human studies in vivo suggested that mulberry leaves has the antidiabetic and its complications activity (Andallu & Varadacharyulu, ; Do et al, ; Volpato et al, ; Zhang et al, ).…”

Section: Introductionmentioning

confidence: 99%

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

Zhu

et al. 2019

Phytotherapy Research

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Mulberry leaf was reported that it has antidiabetic activity, although the mechanisms underlying the function have not been fully elucidated. In the present study, the results of network pharmacology suggested that mulberry leaves could regulate key biological process in development of diabetes, and the process implicates multiple signaling pathways, such as JAK-STAT, MAPK, VEGF, PPAR, and Wnt. Then, the research in vitro indicated that mulberry leaves remarkably ameliorated high glucose-induced epithelial to mesenchymal transition, which was characterized with significant reduction of intracellular reactive oxygen species (ROS) levels as well as downregulation of NADPH oxidase subunits NOX1, NOX2, and NOX4, and it was found to be connected with the ERK1/2 signaling pathway in human tubular epithelial cells (HK-2). Moreover, the results of bioinformatics and the dual luciferase report showed that ZEB1 might be a target gene of miR-302a; decreased miR-302a and increased ZEB1 expressions could significantly promote epithelial to mesenchymal transition. However, mulberry leaves could reverse these modulations. Our results demonstrated that network pharmacology could provide a guidance role for traditional Chinese medicine research, and mulberry leaves could be of benefit in preventing high glucose-induced EMT in HK-2 cells, which proved that it was related to the upregulation of miR-302a by targeting ZEB1 and the inhibition of NADPH oxidase/ROS/ERK1/2 pathway.

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Section: Introductionmentioning

confidence: 99%

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

Zhu

et al. 2019

Phytotherapy Research

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“…As a result, diabetic embryopathy (birth defects and spontaneous abortions) occurs in the sixth to seventh weeks of gestation, and diabetic fetopathy (predominantly macrosomia and fetal hyperinsulinemia) occurs in the second and third trimesters. Freinkel (1980), attributed macrosomia to the increased placental transport of glucose and other nutrients due to an increased availability at the maternal site, resulting in fetal and neonatal macrosomia. Normally, the developing embryo uses both aerobic and anaerobic metabolic pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus (DM) represents the major public health disease and Aluminum (Al) is a well known neurotoxic affecting both human and animal beings. Peripheral nerve involvement is highly frequent in DM and it has been documented that one third of diabetic patients have peripheral neuropathy (Comi and Corbo, 1998;Fazan et al, 2010). Phytotherapy is frequently used throughout the world for a range of diabetic presentations and considered to be less toxic and free from side effects than synthetic drugs (Mutalib, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…For most, there is strong experimental support but the details of each mechanism and their possible interrelationships remain, so far, unanswered (Harati, 2007). Several studies have indicated that hyperglycemia can be controlled via different sorts of medicinal plants (El-Sayyad et al, 2015). Experimental diabetic mice treated with Fructus Ligustri Lucidi (Hao et al, 1992), extract of Ephedrae herba and 1-ephedrine (Xiu et al, 2001), and diabetic rats treated with extract of Matteccia orientalis (Basnet et al,1993), ethanolic extracts of Luffa aegyptiaca (seeds) and Carissa edulis (leaves) (El-Fiky et al,1996), the Chinese herbal mixture [ quei Fu DHW ] (Cheng et al, 2001), hot water Folium Mori extracts (Iizuka et al, 2001), Momordica charantia, Eugenia jambolana, Mucuna pruriens and Tinospora cordifolia (Grover et al, 2001) Smallantus sonchifolius (Aybar et al, 2001), aqueous extract of Rubus fructicosis L. and Globularia alypum L. leaves (Jouad et al, 2002), mulberry (Andallu and Varadacharyulu, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Developmental defects of cerebral cortex in maternally diabetic and aluminum intoxicated rat pups and their amelioration by Morus alba.

Badawy

El-Sayyed

El-Nabi

et al. 2015

Journal of Bioscience and Applied Research

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The present study aimed to investigate the possible ameliorative effect of crude water extract of Morus alba leaves on developmental defects of cerebral cortex of rat pups maternally subjected to diabetes and/or aluminum (Al) intoxication. One hundred and forty fertile male and virgin female albino rats were used for the experimentation. The pregnant rats were arranged into seven groups. The study included five integrated approaches and all proved that treatment with Morus alba leaves extract led to a marked amelioration for the developmental defects caused by either diabetes or Al intoxication at all levels of the study. At the ultrastructural level, the cerebral cortex of the latter exhibited massive cytological alterations of Purkinje cells (PC) and Karyolysis of chromatin material. The cytoplasm appeared translucent and enclosed by either fragmented or vesiculated RER. Mitochondria appeared electron-dense with ill-differentiated cristae. Cytoplasmic vacuoles were detected. However, pups of mothers received Morus alba extract and subjected to Al intoxication and/or diabetes showed partial amelioration of cytological structure of PC. The nuclear envelope was regularly arranged and enclosed by normal euchromatin. The cytoplasmic organelles were rearranged and approximately restored their pattern. It can therefore be concluded that leaves extract of Morus alba has marked ameliorative effects against developmental defects of cerebral cortex in pups of diabetic and Al intoxicated pregnant albino rats.

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“…Possible ameliorative effect of crude water extract of M. alba leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al intoxication was reported. Marked amelioration was observed in the retina of pups maternally received M. alba extract [68].…”

Section: Morus Alba (Mulbery F: Moraceae)mentioning

confidence: 94%

Phytochemical Management of Diabetic Complications, Experimental Evidences

Bisht¹

2019

Asian J Pharm Clin Res

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It is progressively obvious that not only is a cure for the current worldwide diabetes epidemic required but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both Type-1 and Type-2 diabetes. Incidence and pervasiveness of diabetes mellitus are rapid becoming high in middle- and low-income countries where about 80% of people living in those countries depend on traditional medicines. Innumerable and diverse reports abound in the literature on studies conducted to investigate the ameliorative effects of medicinal plants on various pathophysiological complications of diabetes mellitus. Traditional medicines derived from medicinal plants are used by about 60% of the world’s population. Although there are various perspectives to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. The present review emphasizes on medicinal plants that could be beneficial for the treatment of diabetes-induced macrovascular and microvascular complications.

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Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats

Cited by 5 publications

References 49 publications

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

The mechanism of mulberry leaves against renal tubular interstitial fibrosis through ERK1/2 signaling pathway was predicted by network pharmacology and validated in human tubular epithelial cells

Developmental defects of cerebral cortex in maternally diabetic and aluminum intoxicated rat pups and their amelioration by Morus alba.

Phytochemical Management of Diabetic Complications, Experimental Evidences

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