A variety of benzimidazole by the heterocyclization of orthophenylenediamine were synthesized in 69–86% yields. The synthesized compounds
3a-f
and
6a-f
were characterized and further investigated as jack bean urease inhibitors. Density functional theory (DFT) studies were performed utilizing the basis set B3LYP/6-31G (d, p) to acquire perception into their structural properties. Frontier molecular orbital (FMO) analysis of all compounds 3a–f and 6a-f was computed at the same level of theory to get a notion about their chemical reactivity and stability. The mapping of the molecular electrostatic potential (MEP) over the entire stabilized molecular geometry indicated the reactive centers. They exhibited urease inhibition activity with IC50 between 22 and 99 μM. Compounds containing withdrawing groups on the benzene ring (
3d, 6d
) were not showing significant urease inhibition. The value obtained for
3a, 3b, 3f
had shown their significant urease inhibition for both theoretical and experimental. Notably, the compound having S-configuration (
3a
) (22.26 ± 6.2 μM) was good as compared to its R enantiomer
3f
(31.42 ± 23.3 μM). Despite this, we elaborated the computational studies of the corresponding compounds, to highlight electronic effect which include HOMO, LUMO, Molecular electrostatic potential (MEP) and molecular docking.
The Co-catalyzed reactions of 2-halobenzamides and alkynes to form isoquinolones or 2-vinyl benzamides are described. Formation of the two selective products can be fully controlled by adopted ligands. Study of...
A useful oxidation of C–H bond of benzylic acetals
has been
achieved. This method avoids the use of stoichiometric metals and
is compatible with the presence of both electron-donating and electron-withdrawing
substituents on the aromatic ring. Oxidation was carried out by rapid
microwave irradiation of benzylic acetals with PhI(OAc)2 as the oxidant. This led to the oxidation of acetals into 2-acetoxy-1,3-dioxolanes.
Furthermore, this transformation protocol encompasses a wide range
of valuable conversions of these useful synthons into different carboxylic
acid derivatives.
A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures.
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