Introduction: Most important in the evaluation of thyroid thyroid disease is to differentiate a disease that is treated medically from a disease that requires surgical treatment. In preoperative differentiation of a malignant from a benign lesion are used different diagnostic methods (US, scintigraphy, FNAC, MRI). Aim: The aim of the study was to determine the diagnostic value of fine needle aspiration cytology (FNAC) and serum thyroglobulin antibodies (TgAb) values in individual cytological categories. Methods: The prospective study included 100 patients with scintigraphic cold thyroid nodules divided into two groups. The first group consisted of 50 patients with histopathological verified benign nodules and the second group of 50 patients with histopathological verified benign nodules. Demographic datas, FNAC findings, TgAb levels and final histopathological findings were recorded. FNAC with ultrasound (US) guidance was performed by the so-called Free hand technique. TgAtb values were estimated by the radio-immunity assay (RIA) method. Results: In patients with histopathological findings of a benign nodule, 20 patients had a cytological finding of a colloidal nodule, 18 patients had a cellular nodule, 12 had a finding of follicular neoplasm. In patients with a histopathological finding of the malignant nodule, 9 patients had a cytological finding of a colloidal nodule, 8 had a cellular nodule, 21 follicular neoplasm and 12 patients had cancer. FNAC had a sensitivity of 66%, specificity of 76%, a positive predictive value of 73%, a negative predictive value of 69%. The highest preoperative serum TgAb values were in patients with cytologic findings of cancer, and the lowest in the cellular nodule. Conclusion: The finding of FNAC together with serum TgAb values contributes to better diagnosis and selection of patients requiring surgery.
The incidence of incidental gallbladder cancer in this study was 0.69%. The pT-stage is very important factor in overall survival those patients. All cases of pT2-3 incidental GBC should be considered for extended radical resection after cholecystectomy alone.
BackgroundThe aim of the study was to examine on the CT basis the inter-application displacement of the positions D0.1cc, D1cc and D2cc of the brachytherapy dose applied to the bladder and rectum of the patients with inoperable cervical cancer.Patients and methodsThis prospective study included 30 patients with cervical cancer who were treated by concomitant chemo-radiotherapy. HDR intracavitary brachytherapy was made by the applicators type Fletcher tandem and ovoids. For each brachytherapy application the position D0.1cc was determined of the bladder and rectum that receive a brachytherapty dose. Then, based on the X, Y, and Z axis displacement, inter-application mean X, Y, and Z axis displacements were calculated as well as their displacement vectors (R). It has been analyzed whether there is statistically significant difference in inter-application displacement of the position of the brachytherapy dose D0.1cc, D1cc and D2cc of the bladder and rectum. The ANOVA test and post-hoc analysis by Tukey method were used for testing statistical importance of differences among the groups analyzed. The difference among the groups analyzed was considered significant if p < 0.05.ResultsThere are significant inter-application displacements of the position of the brachytherapy dose D0,1cc, D1cc and D2cc of the bladder and rectum.ConclusionsWhen we calculate the cumulative brachytherapy dose by summing up D0,1cc, D1cc and D2cc of the organs at risk for all the applications, we must bear in mind their inter-application displacement, and the fact that it is less likely that the worst scenario would indeed happen.
In the case of the external beam radiotherapy (EBRT) treatment of the prostate cancer there exist two categories of toxicity effects: genito-urinary and gastro-intestinal. The main objective of this work is to investigate the relationships between the total volumes of organs at risk (OARs) and the doses they received in the case of the EBRT treatment of prostate cancer. Knowing these relationships it could be possible to reduce the dose contributions to the OARs by increasing or decreasing their volumes by the intake of an amount of a fluid or applying a special diet during the EBRT treatment and, consequently, in such a way to decrease the possibility of appearing of toxicity effects. Through this work the results obtained by analysis of the data collected from dose volume histograms of 30 patients have been presented. The correlations between the doses received by bladder and rectum and theirs volumes have been investigated. We found the strong significant Pearson’s negative correlations, obtained in the case of bladder between D mean and the volume ratios V/V PTV (r = -0.729 and r = -0.707, p < 0.01) as well as between V 65 and V/V PTV (r = -0.627 and r = -0.605, p < 0.05). In the case of rectum only significant positive Spearman’s correlation was found between D max and V (r = 0.524, p < 0.05). The obtained results impose the necessity for monitoring and applying a special and planned diet, as a part of the whole EBRT treatment of prostate cancer in order to ensure the reproducible conditions for OARs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.