Background: Increased reactive oxygen species disrupt the balance between osteoblasts and osteoclasts. Although the role of training (T) and vitamin D (VD) consumption in bone health has been shown, there is no accurate information on the role of these two interventions on the nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), as an osteoclast marker. Objectives: Therefore, this study aimed to examine the effect of T and VD on NFATc1 gene expression in bone tissue of rats exposed to H2O2. Methods: Fifty adult male Wistar rats aged 8 - 10 weeks and weighing 180 to 220 g were randomly assigned to 10 groups including (1) control (C), (2) dimethyl sulfoxide + normal saline (sham; Sh), (3) 1 mmol/kg H2O2 (1H), (4) 1H+VD, (5) 1H+T, (6) 1H+VD+T, (7) 2 mmol/kg H2O2 (2H), (8) 2H+VD, (9) 2H+T, and (10) 2H+VD+T. The research protocol lasted eight weeks to implement. The levels of NFATc1 gene expression were measured by qRT-PCR. Results: Based on the results, 1H and 2H significantly increased NFATc1 gene expression levels (P = 0.001). However, T (P = 0.001), VD (P = 0.001), and VD+T (P = 0.001) reduced NFATc1 gene expression in the bone tissue of rats exposed to 1 and 2 mmol H2O2. Also, NFATc1 gene expression was significantly lower in the 1H+VD+T group than in the 2H + VD group (P = 0.03). Conclusions: It seems that T and VD consumption both alone and synergistically have a reducing effect on NFATc1 as an osteoclast index in rats exposed to 1 and 2 mmol/kg H2O2.
Background and Aims: Considering the exclusive effects of different training programs on structural, functional, and physiological responses of heart, vessels, and blood, cardiac rehabilitation programs have rehabilitated and therapeutic usage after heart attacks or angioplasty to reduce the rate of deaths caused by cardiovascular diseases. The research aims to examine the effects of two methods, aerobic and parallel exercises, on selected biomechanical variables of blood in the bilateral femoral artery in patients 40-65 years old after coronary angioplasty. Methods: The research method is semi-experimental and prospective. The research was performed as pretest-posttest, with 90 male and female patients with coronary heart disease who had undergone angioplasty divided into three experiments (aerobic and parallel) and control groups. Forty minutes of aerobic exercise based on the American College of Sports Medicine (ACSM) guidelines followed by 20 minutes of resistance training twice a week was performed in the parallel exercise group. The Mean±SD was used for data description, Kolmogorov–Smirnov test was used for reviewing data distribution, Kruskal–Wallis non-parametric and Mann–Whitney post hoc test were used for abnormal variables, and ANOVA, Welch’s test, and Tukey post-hoc test were used for standard variables at a significance level of 0.05. Results: The results showed a significant difference in diastolic blood pressure of the left femoral after performing aerobic and parallel exercises. A significant difference was also seen in the velocity of blood flow in the left femoral’s diastole phase and blood pressure of the left femoral in the systole phase after performing parallel exercises. Comparing the effect of two training methods on selected biomechanical variables of blood, no significant difference was observed between the two methods. Conclusion: It is recommended to use the beneficial effects of aerobic and parallel exercises to improve biomechanical variables of blood with appropriate intensity and duration in patients 40 to 65 years old following coronary angioplasty.
Background: aging is associated with an increase in vascular dysfunction but it can be prevented by exercise training. However, the effect of circuit resistance training as a useful training method in improving cardio-respiratory and muscular strength is unclear. Objectives: The aim of this study was to investigate the effect of CRT on plasma endothelin-1, nitric oxide (NO) and vascular size in aged men. Methods: Twenty healthy aged men (55 ± 5 year) were randomly divided into control and CRT groups. CRT group performed circuit resistance training with 40-60 one repetition maximum for twelve weeks (3 times per week). Vascular size, plasma endothelin-1 and NO, blood pressure and heart rate were measured forty eight hours before and after the training period. Results: CRT increased the vascular size and decreased endothelin-1 and systolic blood pressure compared to the pre-test; however, it had no effect on NO concentration and heart rate. In comparison with the control group, CRT significantly increased the vascular size and decreased endothelin-1 and blood pressure but there was no significant difference in NO concentration and heart rate between the two groups. Conclusions: Circuit resistance training as a proper training method could induce the increase in endothelial function in aged individual and prevents vascular dysfunction related to aging.
Background and Objective: Adipose tissue secrets various hormones including adiponectin, which is closely related to weight control and energy, balance. This study investigated the effects of resistance training on adiponectin, testosterone and cortisol levels in untrained men. Methods: Forty untrained men (mean age of 23.8±2.66 years, mean weight of 67.43 ± 4.96 kg) were randomly and equally assigned into groups of upper extremity resistance training, lower extremity resistance training, combined resistance training, and control. The subjects performed eight weeks of weight training, three sessions per week (five sets of 60-85% one repetition maximum). Blood sampling was done prior to the start of the program, after the fourth week, and after the eight week. Alpha level was set to 0.05 for all statically analyses. Results: Repeated measures ANOVA showed that eight weeks of upper extremities training significantly decreased body fat percentage (p=0.002, 7.39%), and significantly increased adiponectin (p=0.000; 90.42%) and testosterone (p=0.002; 24.19%) levels. In the lower extremities training group, body fat percentage (p=0.006, 7.39%) decreased significantly, while adiponectin (p=0.012; 87.82%) and testosterone (p=0.000; 23.54%) levels increased significantly compared to the pretest. Eight weeks of combined training significantly increased BMI (p=0.006, 1.88%), muscle mass (p=0.007, 2.24%), and adiponectin (p=0.000, 91.56%) level. However, cortisol level decreased (p=0.017, 19.17%) after four weeks of training. Conclusion: Upper and lower extremities resistance trainings significantly change testosterone levels. Different types of resistance training significantly increases serum adiponectin level and changes body composition, which are effective in prevention of cardiovascular diseases.
Background: Exercise and vitamin D can improve bone density by reducing bone loss. Growth factors such as IGF-I and IGFBP-3 are appeared to increase bone turnover in response to mechanical load, and free radicals attenuate the release of these growth factors. Objectives: We assessed the effect of concurrent aerobic training and cholecalciferol administration along with hydrogen peroxide injection on the levels of IGF-I and IGFBP-3 expression in the bone tissue of rats. Methods: Thirty-six adult Wistar rats were randomized into six groups (n = 6), including healthy control, sham, hydrogen peroxide (H2O2), H2O2 + aerobic training, H2O2 + cholecalciferol, and H2O2 + aerobic training + cholecalciferol. The rats were intraperitoneally administered with one mmol/kg. Body weight (BW) of H2O2 three times a week on even days and 0.5 μg/kg.bw of cholecalciferol daily. Aerobic training (at a speed of 4 - 20 m/min, for 20 - 60 minutes) was performed five days/w for eight weeks. The expression of IGF-I and IGFBP-3 was measured by real-time (RT)-PCR. Data were analyzed using the independent t-test, two-way ANOVA (exercise × vitamin D), and Bonferroni’s post-hoc test in SPSS 26 at the significance level of P ≤ 0.05. Results: The results showed that H2O2 significantly reduced the gene expressions of IGF-I (P = 0.001) and IGFBP-3 (P = 0.001) in the bone tissue. Also, exercise and vitamin D augmented the expression of IGF-I (P = 0.008) and IGFBP-3 (P = 0.0001) as post-hoc analysis showed that aerobic training had the greatest effect on the expression of IGF-I and IGFBP-3 (P < 0.05). In addition, the amplifying effects of aerobic training and cholecalciferol on the gene expressions of IGF-I and IGFBP-3 were also remarkable (P < 0.1). Conclusions: The mechanical load created by aerobic training exerted the greatest augmenting effect on the gene expression of IGF-I and IGFBP-3. Moreover, the interactive effect of aerobic training and cholecalciferol was also significant.
The purpose of this research is to defi ne the relationship between anthropometric and physiological variables in elite distance and middle distance runners of Iranian national athletics team for the 3000 m performance. To do this, a sample of 30 elite runners with the mean age of 21.10±0.63 and mean height of 177.8±5.82 and mean weight of 64.26±7.07 were used. Characteristics of anthropometric and physiological and their relationship for the athletes were measured. The Pearson regression with (p≤0.05) was used for this analysis. From 41 variables 8 of them had a meaningful relationship with the performance of athletes which from these body fat mass (kg) and percentage of fat (%) had a positive and meaningful relationship with the performance and a negative and meaningful relationship between distribution of fat and performance. Between VO 2 max (ml/min/kg), anaerobic power, VO 2 max LT (ml/min) and the performance there was a negative and meaningful relationship. Between rest heart rate, breath rate and the performance there was a positive and meaningful relationship.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.