A simple, environmentally benign, cost-effective, and sensitive colorimetric determination for the pharmaceutical drug dexamethasone sodium phosphate (DXP) has been developed by the formation of a colored complex with fluoranil. The process was sensitive and linear over the range 1 to 40 μg/mL, excellent correlation coefficient 0.9989, recovery% 99.80 ± 1.3, limit of detection (LOD) and limit of quantification (LOQ) were 0.23 and 0.9 μg/mL, respectively, and good RSD ~1.63%. The experimental conditions were optimized after an intensive study. The approach was validated statistically for the quantification of the analyte in its pure and/or pharmaceutical form. Despite the proposed approach is selective, it still can be applied for the analysis of other pharmaceuticals.
A new benzylidene derivative, namely 3,, has been synthesized and instrumentally confirmed with Elemental Analysis (CHN), Nuclear Magnetic Resonance (NMR), and Fourier Transform Infrared Spectroscopy (FT-IR). Titanium Dioxide (TiO 2 ) nanoparticles (NPs) were synthesized and characterized by X-ray. The mutualistic complementary dependence of BPTA with TiO 2 nanoparticles as anticorrosive inhibitor on mild steel (MS) in 1.0 M hydrochloric acid has been tested at various concentrations and various temperatures. The methodological work was achieved by gravimetric measurement methods complemented with surface analysis. The synthesized inhibitor concentrations were 0.1 mM to 0.5 mM and the temperatures ranging from 303-333 K. The BPTA with TiO 2 -NP as a synergistic inhibitor becomes superior inhibitive effects with more than 96% inhibition competence of MS coupons in a harsh acidic medium. The efficiency of the inhibition improved with increasing BPTA content and also increase with the Synergistic effects of BPTA with TiO 2 -NP. The excellent effectiveness was performed with the 0.5 mM concentration of BPTA and become higher with adding of TiO 2 -NP rising to the maximum inhibition efficiency (IE). However, the inhibition efficacy declined as the temperature rises. Results of BPTA as corrosion inhibitor indicated the obedience of the adsorption of the inhibitor of mixed type on the surface of MS to Langmuir adsorption isotherm. It was found that the BPTA and performance depend on the Synergistic effects, concentrations of the TiO 2 -NP and BPTA, in addition to the solution temperature. Nevertheless, the quantum calculations have confirmed the direct correlation of the electronic characteristics of BPTA with the corrosive inhibitive influence.
In this work, zinc oxide nanoparticles (ZnO - NPs) were prepared using a sol-gel methodology and tested for their antibacterial activity against each of the following pathogenic species: Escherichia coli, Klebsiella pneumonia, and Staphylococcus aureus by well diffusion assay. The sample prepared was characterized by different techniques: Atomic Force Microscope AFM; Fourier Transform Infrared FT-IR; Scanning Electron Microscope SEM and X-Ray Diffraction Spectroscopy XRD. The XRD result showed that ZnO - NPs presence in wurtzite the structure of ZnO. The AFM and SEM of the surface analysis indicate that the most ZnO – NPs appear approximately in a spherical shape with some agglomeration. The average particle size for ZnO - NPs is nearly 37 nm. Volumes 25µl, 50µl, 75µl, 100µl, 125µl, and 150µl of 10 mg\ ml concentration of ZnO - NPs were used, the antimicrobial activity results showed that ability for ZnO - NPs to inhibit the growth of S.aureus increased as the solution volume increased, while the growing of (K. pneumonia) and (E. coli) was inhibited only with the volume 75µl where the inhibition zones diameters were 15mm and 10mm respectively.
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