Massoidigunakan oleh masyarakat lokal Papua sebagai obat tradisional. Bagian yang dimanfaatkandari tumbuhan ini adalah kulit kayu yang diekstraksi untuk menghasilkan minyak.Pemanfaatan kulit kayu Massoi oleh masyarakat lokal selama ini masih dirasakan kurangoptimal, oleh karena belum banyaknya penelitian terkait kandungan senyawa kimia dankhasiat pengunaan kulit kayu Massoi secara farmakologis. Penelitian ini dilakukan untukmengidentifikasi senyawa bioaktif ekstrak etil asetat kulit kayu Massoi serta mengujiaktivitasnya sebagai antibakteri, antioksidan dan mengetahui tingkat toksisitasnya.Kulit kayuMassoi diekstraksi dengan metode maserasi menggunakan pelarut metanol dan dipartisidengan pelarut air : etil asetat sebesar 12,12 ppm 5050sebesar 44,02 ppm. Hasil pemisahan senyawanya yangdilakukan dengan kromatografi kolom didapat 7 fraksi yang dikelompokkan berdasarkanprofil kromatogram KLT hasil kromatografi kolom yang meliputi bentuk noda, warna, danwaktu retensinya. Hasil analisis KCKT didapatkan fraksi dengan area terbesar terdapat padafraksi 4 sebesar 95042975 pada waktu retensi 10,050 menit. Fraksi 4 dianalisis denganmenggunakan GC-MS untuk mengetahui komponen senyawa yang terdapat di dalamnya,hasil analisisnya didapatkan 13 senyawa terbesar yang mempunyai persen kemiripan antara95-99 % dari data Library program GC-MS.
Streptococcus mutans is considered to play a major etiological role in development of human dental plaque believed to related to dental caries, the most prevalent disease of the human oral cavity. The objectives of the present study were to formulate and produce propolis supplemented-chewing candy and to investigate its antibacterial activity against S. mutans. Propolis is a natural resinous bee-hive product thought to have antimicrobial, anti-inflammatory and immunostimulating activities. Propolis was extracted from hives of bees of Trigona spp. using ethanol. The extract was coated with maltodextrine and homogenized to generate propolis microparticles. The particles were introduced into chewing candy preparations for the production of propolis supplemented-chewing candy. The candy was then subjected to in vitro antibacterial assays to test its activity against S. mutans isolated from human dental plaque. Results showed that the ethanol extracted propolis of Trigona spp. bee-hives can be homogenized to form propolis microparticles. The propolis microparticles could be used as a supplement in the formulation of chewing candy preparations. The propolis supplemented-chewing candy showed antibacterial activity against S. mutans. The candy, therefore, has the potential to be used as an antiplaque agent for prevention of dental caries
This study discussed the right of notaries to refuse the creation of deeds containing usuries by reasons of implementing the principles of sharia and the legal implications of notaries based on Article 16 Law on Notary Position. This study was normative research that used conceptual and legislation approaches. Data collection techniques used library studies. The analysis results showed that notaries had the right to refuse the creation of deeds containing usuries based on the theoretical, juridical, and philosophical aspects. Due to the law of notaries that refused the creation of deeds containing usuries, it violates Article Article 16 Law on Notary Position so that notaries could be subject to tieredly administrative action. The Law on Notary Position had not provided legal protection to notaries who practice their profession under the principles of sharia.
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