Approved
REPOT D CUMETATON PGE0MB
NO. 0704-0188Pubi~c reportingj burden to' chsoli~e".i.n of information iieuriteo t,-fg hour Pei retpeonie ri~dn4lic 1the Utie for r"etoih knwttrnMWte ching e-tigd ata sources. gathering ad maintaining the data needed. adn compleung and retie-ng the collect-ion of ,nto-at,on Send onme~ntt regrding tht b.,den estmhte or anV other atpec-t of I Approved for public release, distribution is unlimited.j
ABSTRACT (Maximum 200 words)Fischer 344 rats and C57BIlJ6 mice were exposed for one year to inhalation concentrations of either 200 or 1000 Ing JP-TS/in3 or 150 or 750 mig JP-7/m~l. A common control group of rats and mice exposed to air alone was maintained under similar exposure conditions. Six animals of each species, sex, and group were sacrificed at the termination of the one-year exposure period. All survivors were maintained for an additional one-year observation period. Significant microscopic findings following the one-year inhalation study were primarily restricted to renal lesions found in male rats. The renal lesions were consistent with changes reported following other hydrocarbon inhalation exposures. Renal neoplasms were slightly increased in number in male rats following the postexposure observation period. No exposu re-related degenerative changes or increased carcinogenesis was noted in mice.
SUBJECTTERMS 15. NUMBEROFPAGES
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