Abstract. The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). Bifemelane (125 -1000 µM) induced a dose-dependent increase in the intracellular calcium concentration ([Ca 2+ ] i ). In the highest concentration (1000 µM), the drug caused the second large increase in [Ca 2+ ] i during the washing. The increase that occurred during the administration partially remained in the Ca
2+-free medium and was blocked by 2-aminoethoxydiphenyl borate (2-APB), an IP 3 -receptor blocker, indicating that the source of Ca ] i induced by bifemelane is not due to its direct effect on the cells, but is dependent upon the ATP released from the cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.