Background: Heart failure with reduced ejection fraction has a significant association with considerable morbidity and mortality, but there is still inadequacy in appropriate treatment to prevent this condition. We observed the effect of angiotensin receptor neprilysin inhibitor (ARNi) with such disorder compared to valsartan. Methods: In this single-blind trial, the patients were enrolled with chronic HF aged on or above 40 years, symptomatic NYHA class II-IV, an elevated NT-proBNP above 400 pg/ml level and a reduced LVEF of 40% or less. The patients were randomly assigned 1:1 to the treatment arms either ARNi (50 mg titrated to 100 mg twice a day) or valsartan (40 mg titrated to 80 mg twice a day) and followed for a median of 88 days. The primary outcome was mode of cardiovascular death and re-hospitalization for heart failure. Changes in the level of NT-proBNP and rate of ejection fraction were also measured. Results: Cardiovascular deaths occurred 4 (8%) in the ARNi treatment arm, while 11 (22%) in the valsartan treatment arm with significant hazard ratio in the ARNi group [Hazard Ratio = 0.37; 95% CI: 0.34, 0.64; p = 0.042] during a median of 88 days of follow up period and 2 (4%) of the patients from the ARNi treatment arm were hospitalized due to HF, while in the valsartan treatment arm, 10 (20%) patients were hospitalized due to HF followed by receiving treatment respectively with hazard ratio in the ARNi group [Hazard Ratio = 0.
Background: Cardiomyopathy is a primary disorder of heart muscle with abnormal myocardial performance. It is an important cause of heart failure and accounts for upto 25% of causes of heart failure. In view of the high prevalence of chronic heart failure due to underlying dilated cardiomyopathy and the lack of data on DCM, the study was undertaken.
Methods: A total of 100 patients (71 males and 29 females) of dilated cardiomyopathy were taken who was undergone Echocardiography at popular Diagnostic centre, Rangpur. ECG and echocardiography was done among all these patients using standard techniques.
Results: Majority of the patient was above the age 50 years with male to female ratio is 2.4 :1. Sinus tachycardia, non specific ST-T change, LVH, non progression of R in v1-v5 were common ECG abnormalities.
Conclusion: ECG may be normal in patients with DCM though sinus tachycardia and non specific ST-T abnormalities were common.
Cardiovasc. j. 2020; 12(2): 109-112
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.