Background: The aim is to study the correlation of serum uric acid and atrial fibrillation in hypertensive individuals and the effect of duration of hypertension on atrial fibrillation & serum uric acid (SUA). Materials and Methods: Patients (age between 35-65years) were selected from outpatient OPD & IPD. A control group of 100 non hypertensive individuals and another group of 100 hypertensive patients were enrolled. Serum uric acid, Echocardiography: A Trans Thoracic Echocardiography (TTE) measurement of Left atrium diameter (LVST), interventricular septal thickness (LVPWT), posterior wall thickness, left ventricular end diastolic diameter (LV) and LV ejection fraction (LVEF) was recorded. Results: Hyperuricemia incidence in controls was 11% and hyperuricemia incidence in cases was 65 %. The incidence of hyperuricemia in cases with phase 1 of hypertension was 6.27±1.22 mg/dl and those with phase 2 of hypertension was 7.59±1mg/dl which was significant. Atrial fibrillation incidence was 4% in the hypertensive patients and the atrial fibrillation incidence in normotensive patients was 1%. Conclusion: Hypertension duration had a significant effect on the SUA levels and revealed that there was noteworthy increase in the SUA level in individuals with atrial fibrillation than those without atrial fibrillation.
Background: Liver is a complex organ, essential for iron metabolism in the body and is recognised as the primary site for the synthesis of iron-related plasma proteins. Liver also regulates iron concentrations in an effective manner and identifies changes in systemic iron requirements. Haematological abnormalities are often associated with chronic liver diseases. Raised iron stores show high response to the infection of hepatitis C, resistance to interferon, therapy & development of CLDs.Objective: This study intends to assess the association of iron parameters with liver enzymes in patients of CLD and to compare these parameters with healthy controls. Material and Methods: This study was carried out from January to December 2021 in the Department of Biochemistry, Teerthanker Mahaveer Hospital. A total of 100 individuals, out of which 50 were chronic liver disease patients and 50 as healthy controls were selected. Serum iron parameters were measured using an automated method. Results: Findings of this study reveals that serum iron and serum transferrin saturation levels were significantly increased (p<0.001), while serum UIBC and TIBC levels were significantly decreased (p<0.001) when compared with healthy controls.
Conclusion:Based on our data we demonstrate that these findings will provide a fair framework for the prognosis of liver diseases and are also likely to be informative for reducing the risk of complications associated with liver diseases.
Background: Diabetes mellitus, a group of metabolic disorders with multiple etiologies is characterized by chronic hyperglycaemia, induced by deficiency of insulin production and insulin action. Prediabetes is a type of hyperglycemia in which glycemic indices are higher than normal but lower than the diabetes threshold.Objective: This study aims to assess the impact of bone markers (serum calcium, phosphorus and alkaline phosphatase) on prediabetic and type 2 diabetes mellitus patients. Material and Methods: This study was carried out in 2021 from January to December, in the Department of Biochemistry, Teerthanker Mahaveer Hospital, and Moradabad. Comparative levels of serum calcium, serum phosphorus and alkaline phosphatase between 65 Prediabetic and 65 Type2 diabetes mellitus patients were measured using an automated method. Results: Serum ALP and serum phosphorus were significantly higher in the diabetic patients than that in the pre diabetic group (p<0.001), whereas serum calcium was significantly lower in type 2 diabetes mellitus patients than that in prediabetes (p<0.001). Conclusion: Our findings depict variations in serum mineral levels are linked to prediabetes and these parameters can be considered as independent predictors for the diagnosis of type II diabetes mellitus, and their early diagnosis could be beneficial to prevent further complications.
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