Study of serum iron parameters in chronic liver disease

Abstract

Background: Liver is a complex organ, essential for iron metabolism in the body and is recognised as the primary site for the synthesis of iron-related plasma proteins. Liver also regulates iron concentrations in an effective manner and identifies changes in systemic iron requirements. Haematological abnormalities are often associated with chronic liver diseases. Raised iron stores show high response to the infection of hepatitis C, resistance to interferon, therapy & development of CLDs.Objective: This study intends to assess the association of iron parameters with liver enzymes in patients of CLD and to compare these parameters with healthy controls. Material and Methods: This study was carried out from January to December 2021 in the Department of Biochemistry, Teerthanker Mahaveer Hospital. A total of 100 individuals, out of which 50 were chronic liver disease patients and 50 as healthy controls were selected. Serum iron parameters were measured using an automated method. Results: Findings of this study reveals that serum iron and serum transferrin saturation levels were significantly increased (p<0.001), while serum UIBC and TIBC levels were significantly decreased (p<0.001) when compared with healthy controls. Conclusion:Based on our data we demonstrate that these findings will provide a fair framework for the prognosis of liver diseases and are also likely to be informative for reducing the risk of complications associated with liver diseases.