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Objective To determine more precisely the effect of prophylactic low dose aspirin on intrauterine growthDesign Meta-analysis of 13 published randomised clinical trials. Methods ConclusionThe results of this meta-analysis showed that early aspirin treatment reduced the risk of intrauterine growth retardation. Low dose aspirin should not be used routinely in pregnant women until those most likely to benefit from aspirin treatment have been clearly identified.retardation and perinatal mortality.

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Cervicovaginal fetal fibronectin is an effective short-term marker of preterm delivery, especially in women with symptoms of preterm labour. Because results appear to be heterogeneous in different studies, caution should be taken when they are applied to a specific population.