Antibiotic treatment in preterm premature rupture of membranes and neonatal morbidity: A metaanalysis

Egarter, Christian; Leitich, Harald; Karas, Hermann; Wieser, Friedrich; Husslein, Peter; Kaiderb, Alexandra; Schemper, M.

doi:10.1016/s0002-9378(96)70433-7

Cited by 135 publications

(47 citation statements)

References 19 publications

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“…17 In this study, early sepsis was not related to chorioamnionitis. An association among chorioamnionitis, sepsis, and IVH in the preterm infant has been reported previously, 11 and the risk of IVH and early sepsis is reduced when antenatal antibiotics are given.…”

Section: Discussionmentioning

confidence: 44%

“…A number of risk factors have been proposed for the development of IVH: low birth weight and gestational age, [1][2][3][4][5][6][7][8] maternal smoking, 9 breech presentation, 5 gender, 5,7,10 premature rupture of membranes, 6,11 intrauterine infection, 6,11-13 mode of delivery, 5,10,11,14,15 prolonged labor, 1,16 postnatal resuscitation and intubation, 1,7,16 transferal from one unit to another, 7,16 early onset of sepsis, 17,18 development of respiratory distress syndrome 7,11 or pneumothorax, 2 recurrent endotracheal suctioning, 1,16 metabolic acidosis and rapid bicarbonate infusion, 10,16 and high-frequency ventilation. 19 Pregnancy-induced hypertension is associated with a lower rate of IVH.…”

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confidence: 99%

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Risk Factors for Intraventricular Hemorrhage in Very Low Birth Weight Premature Infants: A Retrospective Case-Control Study

et al. 2003

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ABSTRACT. Objective. High-grade intraventricular hemorrhage (IVH) is an important cause of severe cognitive and motor neurologic impairment in very low birth weight infants and is associated with a high mortality rate. The risk of IVH is inversely related to gestational age and birth weight. Previous studies have proposed a number of risk factors for IVH; however, lack of adequate matching for gestational age and birth weight may have confounded the results. The purpose of this study was to identify variables that affect the risk of high-grade IVH, using a retrospective and case-control clinical study.Methods. From a cohort of 641 consecutive preterm infants with a birth weight of <1500 g, 36 infants with IVH grade 3 and/or 4 were identified. A control group of 69 infants, closely matched for gestational age and birth weight, was selected. Maternal factors, labor and delivery characteristics, and neonatal parameters were collected in both groups. Results of cranial ultrasound examinations, whether routine or performed in presence of clinical suspicion, were also collected. Univariate analysis and multivariate logistic regression analysis were performed.Results. High fraction of inspired oxygen in the first 24 hours, pneumothorax, fertility treatment (mostly in vitro fertilization), and early sepsis were associated with an increased risk of IVH. A higher number of suctioning procedures, a higher first hematocrit, and a relatively low arterial pressure of carbon dioxide during the first 24 hours of life were associated with a lower occurrence. In the multivariate logistic regression model, early sepsis (odds ratio [

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Section: Discussionmentioning

confidence: 44%

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confidence: 99%

Risk Factors for Intraventricular Hemorrhage in Very Low Birth Weight Premature Infants: A Retrospective Case-Control Study

et al. 2003

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“…3,4,5 intraventricular hemorrhage, necrotizing enterocolitis and sepsis. 5,6,7 Fetal wastage and neonatal mortality and morbidity are high when PROM occurs in pregnancies of less than 32 weeks. The decision for appropriate management depends on the assessment of the gestational age, the likelihood of infection and the availability of neonatal intensive care facilities.…”

Section: Introductionmentioning

confidence: 99%

Perinatal and Maternal Outcome in Prelabour Rupture of Membranes

Minnalkodi¹

2015

jemds

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Prelabour Rupture of Membranes (PROM) is one of the most common complications of pregnancy that has major impact on fetal and maternal outcome. It occurs in 1 out of every 10 pregnancies; 80% of women who present with PROM are term. It is also one of the commonest event where a normal pregnancy can turn into a high risk situation for the mother as well as for the fetus. Despite the relative frequency of this event, clinical management is one issue unresolved by the clinical research till date. A prospective study was designed to know the incidence, etiology, risk factors, fetal and maternal outcomes of prelabour rupture of membrane in Government Chengalpattu Medical College Hospital. One hundred mothers with singleton pregnancy in the age group of 19 to 35 years with leaking per vaginum and without maternal complications interfering with active management of PROM like heart disease, Pregnancy Induced Hypertension (PIH) were chosen and assessed with a standardized protocol. The data was collected and analysed statistically.

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“…6 There are recommendations of antenatal antibiotic administration in pregnant women who had PROM ≥18 hours but the regimen to prevent postnatal neonatal infection still varies among institutions. 7 The objective of this study was to know the incidence of early onset sepsis following PROM more than 18 hours and to know the incidence of mortality among neonates born to mothers with PROM more than 18 hours, and to know the incidence of neonatal infection in neonates born to mothers with history of PROM more than 18 hours who have not received antibiotics before labour.…”

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confidence: 99%

Incidence of morbidity and mortality in neonate born to mothers with premature rupture of membranes

Lokhande

Nistane

2016

Int J Contemp Pediatr

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Antibiotic treatment in preterm premature rupture of membranes and neonatal morbidity: A metaanalysis

Cited by 135 publications

References 19 publications

Risk Factors for Intraventricular Hemorrhage in Very Low Birth Weight Premature Infants: A Retrospective Case-Control Study

Risk Factors for Intraventricular Hemorrhage in Very Low Birth Weight Premature Infants: A Retrospective Case-Control Study

Perinatal and Maternal Outcome in Prelabour Rupture of Membranes

Incidence of morbidity and mortality in neonate born to mothers with premature rupture of membranes

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