Extracellular matrix components play an active role in cancer progression and prognosis. Versican, a large extracellular matrix proteoglycan, can promote cancer metastasis through facilitating cell proliferation, adhesion, migration and angiogenesis. We had previously demonstrated that amiodarone caused ectopic overexpression of similar to versican b (s-vcanb), inhibited EGFR/GSK3β/Snail signaling, and enhanced Cdh5 at the heart field of zebrafish, indicating interference with epithelial-mesenchymal transition (EMT). Since S-vcanb is homologous to mammalian versican V2 isoform, we examined the effects of amiodarone on mammalian tumor proliferation, migration, invasion and metastasis in vitro and in vivo and on EMT signaling pathways. Monolayer wound assays and extracellular matrix transwell invasion assays showed reduced migration and invasion by 15 μM amiodarone treated B16OVA, JC, 4T-1, MDA-MB-231 and MCF-7 tumor cell lines. All cancer cell lines showed reduced metastatic capabilities in vivo after treatment with amiodarone in experimental animals. Western blots revealed that EMT-related transcription factors Snail and Twist were reduced and E-cadherin was enhanced in amiodarone treated cells through an EGFR/ERK/GSK3β-dependent pathway. Immunohistochemistry showed amiodarone lead to increased expression of versican V2 isoform concomitant with reduced versican V1. Our study illustrated the role of versican v2 in EMT modulation and cancer suppression by amiodarone treatment.

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Quantum correlations between spatially separated parts of a d-dimensional bipartite system (d ≥ 2) have no classical analog. Such correlations, also called entanglements, are not only conceptually important, but also have a profound impact on information science. In theory the violation of Bell inequalities based on local realistic theories for d-dimensional systems provides evidence of quantum nonlocality. Experimental verification is required to confirm whether a quantum system of extremely large dimension can possess this feature, however it has never been performed for large dimension. Here, we report that Bell inequalities are experimentally violated for bipartite quantum systems of dimensionality d = 16 with the usual ensembles of polarization-entangled photon pairs. We also estimate that our entanglement source violates Bell inequalities for extremely high dimensionality of d > 4000. The designed scenario offers a possible new method to investigate the entanglement of multipartite systems of large dimensionality and their application in quantum information processing.

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Frequency translation of single photons while preserving their quantum characteristics is an important technology for flexible networking of photonic quantum communication systems.Here we demonstrate a flexible scheme to interface different-color photons using an optical single sideband (OSSB) modulator. By changing the radio-frequency signal that drives the modulators, we can easily shift and precisely tune the frequency of single photons. Using the OSSB modulator, we successfully erased the frequency distinguishability of non-degenerated photon pairs to obtain the Hong-Ou-Mandel interference with a visibility exceeding 90%. We also demonstrated that the level of distinguishability can be precisely controlled by the OSSB modulator. We expect that the OSSB modulator will provide a simple and flexible photonic interface for realizing advanced quantum information systems.

Time-bin qubits, where information is encoded in a single photon at different times, have been widely used in optical fiber and waveguide based quantum communications. With the recent developments in distributed quantum computation, it is logical to ask whether time-bin encoded qubits may be useful in that context. We have recently realized a time-bin qubit controlled-phase (C-Phase) gate using a 2×2 optical switch based on a lithium niobate waveguide, with which we demonstrated the generation of an entangled state. However, the experiment was performed with only a pair of input states, and thus the functionality of the C-Phase gate was not fully verified. In this research, we used quantum process tomography to establish a process fidelity of 97.1%. Furthermore, we demonstrated the controlled-NOT gate operation with a process fidelity greater than 94%. This study confirms that typical two-qubit logic gates used in quantum computational circuits can be implemented with time-bin qubits, and thus it is a significant step forward for realization of distributed quantum computation based on time-bin qubits.

Quantum random numbers distinguish themselves from others by their intrinsic unpredictability arising from the principles of quantum mechanics. As such they are extremely useful in many scientific and real-world applications with considerable efforts going into their realizations. Most demonstrations focus on high asymptotic generation rates. For this goal, a large number of repeated trials are required to accumulate a significant store of certifiable randomness, resulting in a high latency between the initial request and the delivery of the requested random bits. Here we demonstrate low-latency real-time certifiable randomness generation from measurements on photonic time-bin states. For this, we develop methods to certify randomness taking into account adversarial imperfections in both the state preparation and the measurement apparatus. Every 0.12 s we generate a block of 8192 random bits which are certifiable against all quantum adversaries with an error bounded by 2−64. Our quantum random number generator is thus well suited for realizing a continuously-operating, high-security and high-speed quantum randomness beacon.