Background: PML is highly expressed in endothelial cells (ECs), but its role in ECs remains largely unexplored. Results: PML is critical for TNF␣-and IFN␣-mediated inhibition of EC network formation and migration. Conclusion: PML is an angiogenesis inhibitor following inflammation-associated cytokine signaling. Significance: PML is a novel regulator of endothelial cell physiology.

Background:The role of PML in metabolism remains largely unexplored. Results: PML ablation re-patterns energy balance in mice by promoting fatty acid metabolism. Conclusion: PML is an energy sensor that controls gene expression to regulate metabolism. Significance: Our study provides insights into a novel role of tumor suppressor PML in metabolic control.

A La(2/3)Ca(1/3)MnO(3) Hall bar with its long dimension roughly along the hard axis [110] was fabricated on a single-crystal-like tensilely strained film on SrTiO(3)(001). The anisotropic magnetoresistance (AMR) and planar Hall effect (PHE) have been studied at various external magnetic fields and temperatures. A phenomenological model in the high field limit is developed, and the galvanomagnetic tensor based on a tetragonal symmetry 4/mmm (D(4h)), applicable to epitaxial films on a substrate, has been obtained by expanding the tensor to the sixth order. The derived in-plane transverse resistance R(xy) shows a sin2φ(M) angular dependence, while the longitudinal R(xx) is constituted by not only a two-fold cos2φ(M) term, but also a four-fold cos4φ(M) term due to the square symmetry of the lattice. The model is in good agreement with the experimental results in high fields, while deviations are observed near the {100} easy axis with the decreasing field. Close inspection of the fitting parameters reveals the evolution of these term weights with temperature and magnetic field, which is distinct from conventional ferromagnetic metals and cannot be explained by the phenomenological model. An alternative mechanism for AMR, stemming from the magnetization-induced local orbit deformation through spin-orbit interaction, as previously proposed by O'Donnell et al, may be prevalent in manganites and other systems of complicated crystal structure.