Cardiovascular disease is a major cause of death worldwide. New diagnostic tools are needed to provide early detection and intervention to reduce mortality and increase both the duration and quality of life for patients with heart disease. Seismocardiography (SCG) is a technique for noninvasive evaluation of cardiac activity. However, the complexity of SCG signals introduced challenges in SCG studies. Renewed interest in investigating the utility of SCG accelerated in recent years and benefited from new advances in low-cost lightweight sensors, and signal processing and machine learning methods. Recent studies demonstrated the potential clinical utility of SCG signals for the detection and monitoring of certain cardiovascular conditions. While some studies focused on investigating the genesis of SCG signals and their clinical applications, others focused on developing proper signal processing algorithms for noise reduction, and SCG signal feature extraction and classification. This paper reviews the recent advances in the field of SCG.
The fine scale three-dimensional structures usually associated with streamwise vortices in the near wake of a circular cylinder have been studied at Reynolds numbers ranging from 170 to 2200. Spatially continuous velocity measurements along lines parallel to the cylinder axis were obtained with a scanning laser anemometer. To detect the streamwise vortices in the amplitude modulated velocity field, it was necessary to develop a spatial decomposition technique to split the total flow into a primary flow component and a secondary flow component. The primary flow is comprised of the mean flow and Strouhal vortices, while the secondary flow is the result of the three-dimensional streamwise vortices that are the essence of transition to turbulence. The three-dimensional flow amplitude increases in the primary vortex formation region, then saturates shortly after the maximum amplitude in the primary flow is reached. In the near-wake region the wavelength decreases approximately like Re−0.5, but increases with downstream distance. A discontinuous increase in wavelength occurs below Re = 300 suggesting a fundamental change in the character of the three-dimensional flow. At downstream distances (x/D = 10-20), the spanwise wavelength decreases from 1.42D to 1.03D as the Reynolds number increases from 300 to 1200.
An analytical solution is developed for the problem of surface wave generation on a linear viscoelastic half-space by a finite rigid circular disk located on the surface and oscillating normal to it. The solution is an incremental advancement of theoretical work reported in articles focused on seismology. Since the application of interest here is medical diagnostics, the solution is verified experimentally using a viscoelastic phantom with material properties comparable to biological soft tissue. Findings suggest that prior estimates in the literature of the shear viscosity in human soft tissue may not be accurate in the low audible frequency range. Measurement of wave motion on the skin surface caused by internal biological functions or external stimuli has been studied by a few researchers for rapid, nonintrusive diagnosis of a variety of specific medical ailments. It is hoped that the developments reported here will advance these techniques and also provide insight into related diagnostic methods, such as sonoelastic imaging and other methodologies that utilize disease-related variations in tissue shear elasticity or variations in density due to gaseous inclusions.
This study is the first to document the relationships between gastrointestinal sounds and the migrating motor complex. The chronological relation between antral motility and gastrointestinal sounds, and the dissimilar effects of erythromycin and somatostatin, suggest that antral contractions increase gastrointestinal sounds, perhaps by supplying gas into the intestine.
Some pulmonary diseases and injuries are believed to correlate with lung viscoelasticity changes. Hence, a better understanding of lung viscoelastic models could provide new perspectives on the progression of lung pathology and trauma. In the presented study, stress relaxation measurements were performed to quantify relaxation behavior of pig lungs. Results have uncovered certain trends, including an initial steep decay followed by a slow asymptotic relaxation, which would be better described by a power law than exponential decay. The fractional standard linear solid (FSLS) and two integer order viscoelastic models - standard linear solid (SLS) and generalized Maxwell (GM) - were used to fit the stress relaxation curves; the FSLS was found to be a better fit. It is suggested that fractional order viscoelastic models, which have nonlocal, multi-scale attributes and exhibit power law behavior, better capture the lung parenchyma viscoelastic behavior.
Pneumothorax is a common clinical condition that can be life threatening. The current standard of diagnosis includes radiographic procedures that can be costly and may not always be readily available or reliable. The objective of this study was to investigate the hypothesis that pneumothorax causes detectable pathognomonic changes in pulmonary acoustic transmission. An animal model was developed whereby 15 mongrel dogs were anaesthetised, intubated and mechanically ventilated. A thoracoscopic trocar was placed into the pleural space for the introduction of air and confirmation of a approximately 30% pneumothorax by direct visualisation. Broadband acoustic signals were introduced into the endotracheal tube, while transmitted waves were measured at the chest surface. Pneumothorax was found consistently to lower the pulmonary acoustic transmission in the 200-1200 Hz frequency band, whereas smaller transmission changes occurred at lower frequencies (p< 0.0001, sign test). The ratio of acoustic energy between low-(< 220 Hz) and high-(550-770 Hz) frequency bands was significantly different in the control and pneumothorax states (p < 0.0001, sign test). This implies that pneumothoraces can be reliably detected using pulmonary acoustic transmission measurements in the current animal model. Further studies are needed to investigate the feasibility of using this technique in humans.
Symmetric and antisymmetric periodic disturbances introduced directly into the boundary layer on a circular cylinder at low Reynolds number are shown by experiment to be capable of modifying the vortex formation process and changing the vortex shedding frequency. Spectral measurements have shown that the antisymmetric vortex shedding mode is strongly coupled to the symmetric first harmonic mode. When symmetric excitation is applied, three different shapes of the mean velocity profiles can be identified as the forcing amplitude is increased. At low forcing amplitudes nonlinear interaction between the forcing field and the natural wake oscillator produces sum and difference modes. Symmetric forcing with intermediate-amplitude disturbances suppresses the natural shedding frequency, and the dominant vortex shedding energy appears as a sinuous mode at half the excitation frequency. At high symmetric forcing amplitudes a threshold is reached, above which the large-scale vortices do not form. The symmetries of the combination modes follow two simple rules based on the symmetries of the interacting modes. The symmetry rules provide an explanation for the fundamental difference in wake structure that occurs between symmetric forcing and antisymmetric forcing.
Noninvasive measurement of mechanical wave motion (sound and vibration) in the lungs may be of diagnostic value, as it can provide information about the mechanical properties of the lungs, which in turn are affected by disease and injury. In this study, two previously derived theoretical models of the vibroacoustic behavior of the lung parenchyma are compared: (1) a Biot theory of poroviscoelasticity and (2) an effective medium theory for compression wave behavior (also known as a "bubble swarm" model). A fractional derivative formulation of shear viscoelasticity is integrated into both models. A measurable "fast" compression wave speed predicted by the Biot theory formulation has a significant frequency dependence that is not predicted by the effective medium theory. Biot theory also predicts a slow compression wave. The experimentally measured fast compression wave speed and attenuation in a pig lung ex vivo model agreed well with the Biot theory. To obtain the parameters for the Biot theory prediction, the following experiments were undertaken: quasistatic mechanical indentation measurements were performed to estimate the lung static shear modulus; surface wave measurements were performed to estimate lung tissue shear viscoelasticity; and flow permeability was measured on dried lung specimens. This study suggests that the Biot theory may provide a more robust and accurate model than the effective medium theory for wave propagation in the lungs over a wider frequency range.
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