The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Clavicepspurpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl2 (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.

In einer groi3en Zahl von Arbeiten wird die fermentative Produktion von Citronensaure (CS) und gleichzeitig Isocitronensaure (ICS) aus n-Alkanen durch Hefen der Gattung Candida beschrieben.