Solving the water scarcity problem by enhancing water extraction from air technology.

Summary Capturing water vapor from atmospheric air is a possible solution to local water scarcity, but it is very energy demanding. Energy consumption estimates of water-from-air technologies involving adsorption processes, thermo-responsive hydrophilicity switching polymers, air cooling processes, and reverse osmosis of deliquescent salt solutions reveal that these technologies are not competitive when compared with seawater desalination, and the use of fresh water and wastewater sources. They only become a viable option in the absence of local liquid water sources and when long-distance transport for socio-economic reasons is not an option. Of interest, direct solar-driven technology for water-from-air production is an attractive means to disentangle the local water-energy nexus. It is expected that climate change will accelerate the introduction of water-from-air technologies in local water supply schemes. The optimal water-from-air technology depends on the climate, relative humidity, and temperature profiles. A world map is presented, indicating the optimal geographic location for each technology.

Porous silica is used as a drug delivery agent to improve the bioavailability of sparsely soluble compounds. In this approach, the active pharmaceutical ingredient (API) is commonly loaded into the porous silica by incipient wetness impregnation using organic solvents. Subsequent solvent elimination is critical as the residual solvent concentration cannot exceed threshold values set by health and safety regulations (e.g., EMA/CHMP/ICH/82260/2006). For dichloromethane and methanol, for example, residual concentrations must be below 600 and 3000 ppm, respectively. Today, EU and USA Pharmacopoeias recommend tedious procedures for residual solvent quantification, requiring extraction of the solvent and subsequent quantification using capillary gas chromatography with static headspace sampling (sHS-GC). This work presents a new method based on the combination of standard addition and absolute quantification using magic-angle spinning nuclear magnetic resonance spectroscopy (MAS qNMR). The methodology was originally developed for absolute quantification of water in zeolites and has now been validated for quantification of residual solvent in drug formations using mesoporous silica loaded with ibuprofen dissolved in DCM and MeOH as test samples. Interestingly, formulations prepared using as-received or predried mesoporous silica contained 5465 versus 484.9 ppm DCM, respectively. This implies that the initial water content of the silica carrier can impact the residual solvent concentration in drug-loaded materials. This observation could provide new options to minimize the occurrence of these undesired solvents in the final formulation.