COVID-19 pandemic
caused by the severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) has become the world’s largest
public health emergency of the past few decades. Thousands of mutations
were identified in the SARS-CoV-2 genome. Some mutants are more infectious
and may replace the original strains. Recently, B.1.1.7(Alpha), B1.351(Beta),
and B.1.617.2(Delta) strains, which appear to have increased transmissibility,
were detected. These strains accounting for the high proportion of
newly diagnosed cases spread rapidly over the world. Particularly,
the Delta variant has been reported to account for a vast majority
of the infections in several countries over the last few weeks. The
application of biosensors in the detection of SARS-CoV-2 is important
for the control of the COVID-19 pandemic. Due to high demand for SARS-CoV-2
genotyping, it is urgent to develop reliable and efficient systems
based on integrated multiple biosensor technology for rapid detection
of multiple SARS-CoV-2 mutations simultaneously. This is important
not only for the detection and analysis of the current but also for
future mutations. Novel biosensors combined with other technologies
can be used for the reliable and effective detection of SARS-CoV-2
mutants.
Noncanonical G-quadruplex nucleic acid structures can be used as probes in biosensors for detection of metal ions, proteins and nucleic acids. Angiotensinogen (AGT) is a glycosylated globulin found in serum,...
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