Cancer chemotherapy typically relies on drug endocytosis and inhibits tumor cell proliferation via intracellular pathways; however, severe side effects may arise. In this study, we performed a first attempt to develop macromolecular‐induced extracellular chemotherapy involving biomineralization by absorbing calcium from the blood through a new type of drug, polysialic acid conjugated with folate (folate‐polySia), which selectively induces biogenic mineral formation on tumor cells and results in the pathological calcification of tumors. The macromolecule‐initiated extracellular calcification causes cancer cell death mainly by intervening with the glycolysis process in cancer cells. Systemic administration of folate‐polySia inhibited cervical and breast tumor growth and dramatically improved survival rates in mice. This study provides an extracellular therapeutic approach for malignant tumor diseases via calcification that is ready for clinical trials and offers new insights into macromolecular anticancer drug discovery.
A number of enamine-functionalized 1,2,3-triazole derivatives have been prepared via the Cu-catalyzed three-component reaction of terminal alkyne, azide, and 2H-azirine. The reaction proceeds through insertion of vinyl nitrene into the C-Cu bond of the triazolyl-Cu species, providing an efficient and step- and atom-economic approach to the enamine-bearing polysubstituted 1,2,3-triazoles. The resulting triazoles were easily transformed to trisubstituted pyrazoles in the presence of a Rh catalyst.
In this paper, a bandpass transmission filter realized in phase-shifted waveguide gratings based on photonic crystals (PCs) is proposed. Phase-shift regions each composed of one period of photonic crystal (PC) waveguide are incorporated into PC waveguide gratings. The magnitudes of the phase-shifts are modified by involving small changes in the size of the border rods in the phase-shift regions. Using standard coupled-mode theory and finite-difference time-domain (FDTD) method, we show that by properly choosing the magnitudes of phase-shifts and the lengths of waveguide gratings, a flat-top and sharp roll-off response with a narrow bandwidth is theoretically and numerically achieved by the designed filter. A further analysis shows that the center frequency of the transmission band can be changed by altering the magnitude of the phase-shift and the response performance exhibits relaxed sensitivity to the phase-shift variation. As a specific application, we theoretically demonstrate a third-order Chebyshev bandpass filter based on compound phase-shifted PC waveguide gratings. The filter performance is suitable for dense wavelength-division-multiplexed (DWDM) optical communication systems with a channel spacing of 100-GHz.
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