Ibuprofen contamination from water sources has been increasingly alarming due to its environmentally accumulative retention; however, the strategies for ibuprofen-containing water treatment are still an enormous challenge. Herein, we described the utilization of metal-organic frameworks MIL-53(Fe) (MIL = Materials of Institute Lavoisier) for the adsorption of ibuprofen in synthetic solution. Firstly, the MIL-53(Fe) was solvothemally synthesized and then characterized using the X-ray diffraction and Fourier-transform infrared spectroscopy techniques. The optimization of ibuprofen adsorption over MIL-53(Fe) was performed with three independent variables including ibuprofen concentration (1.6–18.4 mg/L), adsorbent dosage (0.16–1.84 g/L), and pH (2.6–9.4) according to the experimental design from response surface methodology. Under the optimized conditions, more than 80% of ibuprofen could be eliminated from water, indicating the promising potential of the MIL-53(Fe) material for treatment of this drug. Kinetic and isotherm models also were used to elucidate the chemisorption and monolayer behavior mechanisms of ibuprofen over MIL-53(Fe).

Five coordination sites of Cu(ii) cluster were found in VNU-18 that showed highly efficient catalytic property for the oxidative C–H activation via N–H bonds.

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Chloramphenicol (CAP) is commonly employed in veterinary clinics, but illegal and uncontrollable consumption can result in its potential contamination in environmental soil, and aquatic matrix, and thereby, regenerating microbial resistance, and antibiotic-resistant genes. Adsorption by efficient, and recyclable adsorbents such as mesoporous carbons (MPCs) is commonly regarded as a “green and sustainable” approach. Herein, the MPCs were facilely synthesized via the pyrolysis of the metal–organic framework Fe3O(BDC)3 with calcination temperatures (x °C) between 600 and 900 °C under nitrogen atmosphere. The characterization results pointed out mesoporous carbon matrix (MPC700) coating zero-valent iron particles with high surface area (~225 m2/g). Also, significant investigations including fabrication condition, CAP concentration, effect of pH, dosage, and ionic strength on the absorptive removal of CAP were systematically studied. The optimal conditions consisted of pH = 6, concentration 10 mg/L and dose 0.5 g/L for the highest chloramphenicol removal efficiency at nearly 100% after 4 h. Furthermore, the nonlinear kinetic and isotherm adsorption studies revealed the monolayer adsorption behavior of CAP onto MPC700 and Fe3O(BDC)3 materials via chemisorption, while the thermodynamic studies implied that the adsorption of CAP was a spontaneous process. Finally, adsorption mechanism including H-bonding, electrostatic attraction, π–π interaction, and metal–bridging interaction was proposed to elucidate how chloramphenicol molecules were adsorbed on the surface of materials. With excellent maximum adsorption capacity (96.3 mg/g), high stability, and good recyclability (4 cycles), the MPC700 nanocomposite could be utilized as a promising alternative for decontamination of chloramphenicol antibiotic from wastewater.

We have described an efficient method for oxidative cross coupling reactions between activated N–H amines and terminal alkynes using heterogeneous Cu2(BDC)2(BPY) as recyclable catalyst (BDC = benzene-1,4-dicarboxylate; BPY = 4,4′-bipyridine).

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BackgroundBreast cancer (BC) is one of the leading cancers in women. Recent progress has enabled BC to be cured with high efficiency. However, late detection or metastatic disease often renders the disease untreatable. Additionally, relapse is the main cause of death in BC patients. Breast cancer stem cells (BCSCs) are considered to cause the development of BC and are thought to be responsible for metastasis and relapse. This study aimed to target BCSCs using dendritic cells (DCs) to treat tumor-bearing humanized mice models.Materials and methodsNOD/SCID mice were used to produce the humanized mice by transplantation of human hematopoietic stem cells. Human BCSCs were injected into the mammary fat pad to produce BC humanized mice. Both hematopoietic stem cells and DCs were isolated from the human umbilical cord blood, and immature DCs were produced from cultured mononuclear cells. DCs were matured by BCSC-derived antigen incubation for 48 hours. Mature DCs were vaccinated to BC humanized mice with a dose of 106 cells/mice, and the survival percentage was monitored in both treated and untreated groups.ResultsThe results showed that DC vaccination could target BCSCs and reduce the tumor size and prolong survival.ConclusionThese results suggested that targeting BCSCs with DCs is a promising therapy for BC.