Background/aim: This study aimed to investigate the effect of clinical and pathological indicators at the time of the diagnosis on overall survival in patients recently diagnosed with non-small cell lung cancer.

Objective: The study aims to investigate the effects of clinicopathological characteristics and laboratory data at the time of diagnosis and of the administered treatments on survival in patients with pancreatic cancer. Material and Methods: In this retrospective cohort study, we included the patients who presented to the Medical Oncology Outpatient Clinic of Isparta Süleyman Demirel University Medical Faculty Hospital and were diagnosed with pancreatic cancer between January 1, 2010 and December 31, 2017. Results: A total of 124 patients were examined. The median survival time was 6.97 (%95 CI:4.663-9.270) months, and the 5-year survival rate was 8%. The survival time was shorter in patients diagnosed with adenocarcinoma (HR: 5.350), history of alcohol use (HR: 2.195), an Eastern Cooperative Oncology Group (ECOG) performance score of >2 (HR:2.763), Ca 19-9 value >400 (HR:1.790). Stages 2, 3 and 4 posed 2.034, 3.175 and 6.023 times higher risk of death than stage 1, respectively. Considering the adjuvant chemotherapy group as reference, risk of death was 1.250 times higher for those who received palliative chemotherapy and 2.314 times higher for those who did not receive chemotherapy. Conclusion: In conclusion, history of alcohol use, Ca 19-9 level, ECOG performance status, disease stage, histopathological subtype of the disease, and whether the patient received chemotherapy or radiotherapy affect survival in patients with pancreatic cancer.

Bu çalışma Üçüncü El Sigara Dumanı Hakkında Farkındalık Ölçeğini Türkçeye uyarlamak, geçerlik ve güvenirliğini değerlendirmek amacıyla yapılmıştır. Gereç ve YöntemMetodolojik tipteki çalışma katılma kriterlerini karşılayan 315 kişi ile yapılmıştır. Veri toplama aracı olarak, araştırmacılar tarafından geliştirilen anket formu ve Üçüncü El Sigara Dumanı Hakkında Farkındalık Ölçeği kullanılmıştır. Güvenilirlik çalışmaları için madde analizi, Cronbach alfa katsayısı hesaplanmıştır. Ölçeğin geçerliliğini değerlendirmek için açıklayıcı ve doğrulayıcı faktör analizi yöntemleri uygulanmıştır. BulgularÖlçeğin Kaiser-Meyer Olkin katsayısının 0.695 ve Bartlett testinin ki-kare değeri 661.77 ve sonucun anlamlı olduğu (p<0.001) görülmüştür. Maddelerin faktör yüklerine bakıldığında 0. 512 ile 0.829 arasında değişim göstermektedir. Ölçeğin iç tutarlılık katsayısının 0.71 olarak bulunmuştur. SonuçYapılan geçerlik ve güvenirlik analizleri sonucunda Üçüncü El Sigara Dumanı Hakkında Farkındalık Öl-çeğinin 9 madde ve 2 alt boyuttan oluşan Türk toplumu için geçerli ve güvenilir bir ölçek olduğu görülmüştür.

Background/Aim: Hodgkin lymphoma (HL) is a lymphoproliferative malignancy associated with inflammation. Plateletcrit (PCT) is a mean platelet volume (MPV) and platelet count-derived marker that is useful for evaluating malignancies and inflammatory diseases. International Prognostic Score (IPS-7) and more recently, IPS-3, are two indices indicating the prognosis of patients; however, widespread and easy to interpret prognostic markers are still needed for HL evaluation. Very few studies evaluating the prognostic significance of platelet indices in HL have been published, so we aimed to show the relationship between PCT and other adverse prognostic factors in HL and evaluate whether PCT can be used as a prognostic marker in HL. Methods: After excluding patients with insufficient data, 75 patients diagnosed with HL and 150 healthy controls were retrospectively analyzed in this case-control study. Evaluation of relationship of PCT and adverse HL prognostic factors, such as age, gender, hemoglobin, leukocytes, lymphocytes (absolute value and percentage), albumin, Ann Arbor stage and B symptoms, IPS-3 and-7 prognostic scores and post-treatment relapse, and progression-free survival of the patients were studied. Results: Mean MPV values were significantly lower, mean platelet values were significantly higher inpatient group (all P<0.001). Patients with high sedimentation had significantly higher mean PCT than those without (P=0.031) and a moderately positive correlation between PCT and sedimentation were found (r=0.33, P<0.01). Mean PCT values after treatment significantly decreased compared to baseline levels (P<0.001). Conclusion: PCT may be useful as a prognostic marker in HL. Further studies were needed to evaluate the relationship between PCT and other prognostic factors, such as IPS-3 and -7.

No abstract