This study was an evaluation of pupil response at different light amplitudes in healthy individuals in different age groups. Methods: A total of 210 eyes of 105 healthy individuals were included in the study. The participants were divided into 4 groups at 15-year age intervals: 15-30, 31-45, 46-60, and over 60 years. The dimensions of the pupil were measured with a pupillometer at 5 different light amplitudes: 0, 1, 10, 100, and 200 cd/m 2 . The average pupil diameter in the groups was compared and changes in pupil diameter were correlated for each light amplitude according to age. Results: The mean pupil diameter was 4.96+0.82 mm in males, and 4.95+0.87 mm in females at 0 cd/m 2 light amplitude, and 2.44+0.19 mm and 2.40+0.19 mm, respectively, at 200 cd/m 2 light amplitude. The differences were not statistically significant (p>0.05). In addition, there was no significant difference in pupil size between the right and left eye at any light amplitude (p>0.05). Pupil diameters were found to be smaller at all light amplitudes with advanced age. There was a negative significant correlation between pupil size and age at all light amplitudes (p<0.05). The correlation was stronger at low light amplitudes.
Conclusion:Pupil response to light is influenced by age. This should be taken into consideration when evaluating pupil reaction.
The use of HCQ seems to cause retinal toxicity more often in RA patients compared to SLE patients. For the early detection of retinal changes, OCT and mfERG can be used as screening tools due to their higher sensitivity rates compared to other tests.
RAI administration causes prominent inflammatory response in lacrimal glands. Addition of CoQ10 ameliorates the oxidative damage and protects lacrimal glands both in histopathological and tissue cytokine level assessments. Protection of lacrimal glands against oxidative damage may become a new era of CoQ10 use in the future.
Purpose To determine the effects of selenium, melatonin, and selenium + melatonin administered for one month on anterior chamber (AC) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with ocular ischemic syndrome. Materials and Methods Thirty-five patients were included in the study. Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group. AC samples were obtained. MDA and GSH levels in AC samples were evaluated. Results MDA levels were significantly increased in ischemia groups. Selenium and melatonin supplementation resulted in reduction of MDA levels and significant increase in GSH values. Discussion Increased lipid peroxidation associated with ischemia of the anterior segment has been prevented by selenium and melatonin supplementation. This trial is registered with ClinicalTrials.gov NCT04005222.
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