Coenzyme Q10 for the Protection of Lacrimal Gland against High-Dose Radioiodine Therapy-Associated Oxidative Damage: Histopathologic and Tissue Cytokine Level Assessments in an Animal Model

Yakin, Mehmet; Ekşioğlu, Ümit; Sadic, Murat; Koca, Gökhan; Ozkan-Uney, Guner; Yumuşak, Nihat; Telek, Hande Hüsniye; Demir, Ayten; Yazıhan, Nuray; Örnek, Firdevs; Korkmaz, Meliha

doi:10.1080/02713683.2017.1362006

Cited by 16 publications

(9 citation statements)

References 27 publications

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“…Coenzyme Q10 prevents peripheral neuropathy and neuropathic pain and attenuates neuron loss ( 55 , 56 ). Eyedrops containing crosslinked hyaluronic acid and CoQ10 restore the health of ocular surface ( 57 ), and coenzyme Q10 protects lacrimal glands against the oxidative stress ( 58 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of multivitamin drug on intractable dry eye symptoms

2022

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Dry eye is a disorder of tear film and ocular surface characterized by ocular discomforts. It is associated with multiple causes and sometimes intractable. We investigated the effect of oral multivitamin supplementation (MVG) on dry eyes. Tear break-up time (TBUT), fluorescein ocular surface staining score, and tear secretion Schirmer test were measured in dry eye patients refractory to conventional topical treatment. The ocular surface disease index (OSDI), visual analog pain score (VAS), and modified standardized patient evaluation of eye dryness questionnaire were analyzed. In total, 42 eyes of 42 patients were included. TBUT increased at 1 and 3 months compared to baseline (p < 0.05). OSDI decreased at 1 and 3 months compared to baseline (p < 0.05). VAS score, impact on life, and frequency of total symptoms decreased at 3 months compared to baseline (p < 0.05). Oral administration of MVG, a vitamin complex formulation, was effective in stabilizing tear stability and alleviating symptoms in patients with intractable dry eye. Thus, it may be a viable treatment option for intractable dry eye.

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Section: Discussionmentioning

confidence: 99%

Effect of multivitamin drug on intractable dry eye symptoms

2022

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“…Group 1 (control) was given no treatment. For treatment-experiment groups (Group 2 and Group 3) were given standard therapy as according to previous similar studies (28). In Group 2 (RAI), radioiodine-131 (Mon-Iyot-131, Eczacıbaşı) was applied at 3 mCi/kg via orogastric route.…”

Section: Experimental Designmentioning

confidence: 99%

“…It prevents oxidation and lipid peroxidation in the cell membrane and thereby plays a role in the control of apoptosis. In addition, it shows an anti-inflammatory effect by reducing inflammatory mediators like IL, cytokine and TNF-α (15,23,28). CoQ10 has been widely used for the prevention and treatment of various diseases, such as renal (18), cardiovascular (20) and neural diseases (16).…”

Section: Introductionmentioning

confidence: 99%

Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage

Yumuşak

Koca

Akbulut

et al. 2022

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The aim of this study was to investigated anti-proliferative and antiapoptotic effects of coenzyme Q10 (CoQ10) in the prevention of radioiodine-131 (RAI) (I 131 ) induced kidney damage. A total of Wistar albino rats were separated into equal three groups (n = 8/group): Group 1 (control): untreated group; Group 2 (RAI): mCi/kg RAI oral route; Group 3 (RAI+CoQ10): 3 mCi/kg RAI oral route and intraperitoneally 30 mg/kg/day CoQ10. CoeQ10 treatment was started two days before RAI administration and was continued five days once daily after RAI.Pathomorphological parameters of kidneys were measured using hematoxylin-eosin and Masson's trichrome staining. Immunohistochemically; proliferating cell nuclear antigen (PCNA), caspase 8, caspase 9 and terminal deoxynucleotidyl transferasemediated deoxyuridine triphosphate nick end labeling (TUNEL) were used to determine proliferation and apoptosis. With the exception of the control group, varying degrees of inflammation, degeneration, necrosis, and interstitial/perivascular fibrosis were detected in the kidneys of all rats. This histopathological damage was found to be significantly less in CoQ10 group versus RAI group (P<0.05). The all immunohistochemical examinations demonstrated that administration of CoQ10 had reduced proliferation and apoptosis (P<0.05). The results of kidney histopathology and immunohistochemistry demonstrated that administration of CoQ10 had reduced inflammation, proliferation, and apoptosis. These findings show CoQ10 can play an important role in the radioprotection of kidneys against RAI-induced damage.

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“…Although the antioxidant capacity of CoQ10 appears to be integral to its ability to protect the heart from adriamycin toxicity [ 78 ], its anti-inflammatory function has also been reported to play a central role in attenuating radiotherapy-associated cellular damage. In a study by Yakin et al [ 79 ], it was found that radioiodine treatment caused pronounced inflammatory response in the lacrimal glands (exocrine glands located above the eyeball); this was indicated by oxidative damage to the tissue, decreased total antioxidant status, and increased levels of the pro-inflammatory cytokines TNF and IL-6. CoQ10 treatment increased the total antioxidant status as well as decreasing the levels of TNF and IL-6.…”

Section: Coq10 and Immune Function In Cancermentioning

confidence: 99%

“…Typically, doses in the range of 5 to 50 mg/kg/d have been administered to patients with documented low levels of tissue CoQ10 or mitochondrial disease [ 83 ], although there is limited data on the therapeutic doses required to modulate the immune system. Doses ranging from 10–30 mg/kg/day have shown some efficacy in rat studies, although the doses used in humans have varied considerably, with few taking into account human body weight [ 79 , 80 ]. Furthermore, no therapeutic target plasma levels of CoQ10 have so far been determined for optimal immunomodulatory activity.…”

Section: Coenzyme Q10 Monitoring and Dosagementioning

confidence: 99%

Coenzyme Q10 and Immune Function: An Overview

2021

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Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of oxidative phosphorylation to occur with the concomitant production of ATP, together with its role as a potential lipid-soluble antioxidant, protecting the cell against free radical-induced oxidation. Furthermore, CoQ10 has also been reported to have an anti-inflammatory role via its ability to repress inflammatory gene expression. Recently, CoQ10 has also been reported to play an important function within the lysosome, an organelle central to the immune response. In view of the differing roles CoQ10 plays in the immune system, together with the reported ability of CoQ10 supplementation to improve the functioning of this system, the aim of this article is to review the current literature available on both the role of CoQ10 in human immune function and the effect of CoQ10 supplementation on this system.

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Coenzyme Q10 for the Protection of Lacrimal Gland against High-Dose Radioiodine Therapy-Associated Oxidative Damage: Histopathologic and Tissue Cytokine Level Assessments in an Animal Model

Cited by 16 publications

References 27 publications

Effect of multivitamin drug on intractable dry eye symptoms

Effect of multivitamin drug on intractable dry eye symptoms

Proliferative and apoptotic evaluations of renal preventive effects of coenzyme Q10 in radioiodine-131 induced renal damage

Coenzyme Q10 and Immune Function: An Overview

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