Aim of the work:the present study was carried out to investigate the possible ameliorating effects of three herbs: hops(H) 1.5g/kg diet , rosemary(R) 5g/kg diet and cat's claw (C C) 1.7g/kg diet on hepatic toxicity induced by 7,12-Dimethyl benz(A)antheracene , a hydrocarbon involves various negative consequence for human health and ecosystems conversation .Results:in this work,48 female rats at 50 day of age were divided into 8 groups; control ,hops(H), rosemary(R), cat ' s claw(CC),DMBA, DMBA+H,DMBA+R and DMBA+CC groups.Results:the results indicated that a single intraperitonial (i.p) dose of DMBA (30mg/Kg b.W) caused significant decrease in the percentage of body weight gain, but an increase in the hepatosomatic index. In addition , the results illustrated an increase in the liver malondialdehyde (MDA) contents and hydrogen peroxide levels (H2O2) accompanied by significant decrease in reduced glutathione (GSH) content and superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities.The results, also reported significant decrease in serum total proteins, total albumin , globulin and liver total protein but serum total bilirubin was significantly elevated in the DMBA intoxicated group. Furthermore, aspartate aminotransaminase (ASAT), alanine aminotransaminase (ALAT) , γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities were significantly increased in serum but significantly decreased in the liver. On the other hand, intake of hops, rosemary and cat ' s claw minimize the disturbances observed in most of the tested parameter's resulted from DMBA administration and improve the liver functions mostly in the following order, rosemary ˃ hops ˃ cat's claw. Conclusion: it can be concluded that intake of such herbs (hops , rosemary, cat ' s claw)may be effective in reducing DMBA toxicity.
Aim: Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer. The objective of this study was to elucidate the synergistic effect and the role of chicory extract [inulin (IN)] as a chemo-sensitizer for cisplatin (CIS) treatment of HCC. Methods: Five groups of rats were treated for 4 months. These groups consisted of the control group, a group receiving thioacetamide (TAA) (200 mg/kg b.w) in drinking water, a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) in addition to TAA for 4 months, a group receiving oral doses of IN (10 mg/kg b.w) in addition to TAA for 4 months, and a group injected intraperitoneally with a single dose of CIS (7.5 mg/kg b.w) and IN (10 mg/kg b.w) plus TAA for 4 months. Results: The current data exhibited increment of serum and liver enzyme ( alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatine kinase, and lactate dehydrogenase) activity, serum lipid profi le levels (total lipids, total cholesterol, triglycerides, low-density lipoprotein, and very low-density lipoprotein), and a signifi cant increase in α-fetoprotein and bilirubin, accompanied with reduced total serum protein and albumin levels in a HCC rat model. Histopathologically, numerous alterations were detected in hepatic tissues of HCC rats, such as lymphocytic cell infi ltration, damage of hepatocytes, dilated congested central vein with degenerated endothelial cells, and congested blood sinusoids in addition to Masson's trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi brosis. Treatment of HCC rats with CIS or IN improved such deleterious effects, where IN is more effective than CIS, and the best effect can be observed in rats that received both CIS and IN. Conclusion: It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model. Key words: Chicory; cisplatin; hepatocellular carcinoma; inulin INTRODUCTIONCancer is one of the most anxiety-inducing diseases and it is presenting with further prolongation and increasing occurrence.[1] The most common and recurrent primary malignancy of the liver is recognized as hepatocellular carcinoma (HCC), a major malignancy worldwide and is increasingly associated with cancer-related death.[2] HCC represents the most common primary malignancy of the liver. According to epidemiological surveys, the prevalence Synergistic curative effect of chicory extract and cisplatin Synergistic curative effect of chicory extract and cisplatin against thioacetamide-induced hepatocellular carcinoma against thioacetamide-induced hepatocellular carcinoma This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the ...
This study was conducted to elucidate the effect of two types of antioxidants containing compounds on some physiological components of laying hens for 8 weeks as well as egg quality with special reference to egg yolk cholesterol concentration. Ninety six adult Shaver White laying hens were randomly divided into six groups ,each contained sixteen birds , control group, two garlic groups (fed on basal diet plus 1g or 3g/kg), two yeast groups (fed on basal diet plus 2g or 4g /kg), and the last group received basal diet plus a mixture of 3g garlic and 4g yeast /kg. Feed intake significantly increased in groups received garlic (3g/kg) and that received garlic and yeast together, while egg weight , Haugh unit and egg mass, were not significantly affected but egg production percent significantly improved. Egg yolk cholesterol significantly declined in all treated groups, especially in that given both garlic and yeast. serum total lipids, triglycerides, cholesterol as well as LDL-C significantly declined in most treated groups while serum HDL-C significantly increased in the groups receiving garlic (3g/kg) or both garlic and yeast. Also serum total protein and albumin levels increased in the group supplemented with both garlic and yeast. Serum levels of estrogen and progesterone significantly increased in the group receiving both garlic and yeast. In conclusion dietary garlic and yeast powder can be used for laying hens to increase egg quality , since, they have a cholesterol-lowering effect.
Quadriacanthus aegypticus n. sp., a monogenean from the gills of Clarias lazera inhabiting Nile delta waters in Egypt, is described. The genus Quadriacanthus Paperna, 1961 is reported for the first time in Egypt. Particular attention has been paid to the reproductive system, the digestive system, the anterior adhesive glands, the posterior body glands and haptoral sclerites. Possible functions of the different internal organs are discussed. The diagnosis of the genus Quadriacanthus is emended.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.