In this study, we reported a simple and efficient route for the one-pot sonochemical synthesis of substituted 3-pyrrolin-2-ones by citric acid as an additive.
An easy and convenient method is reported for the synthesis of polyhydroquinoline derivatives in solvent-free conditions under microwave irradiation in the presence of magnetic nickel ferrite nanoparticles (NiFe 2 O 4 MNPs) as a catalyst. Excellent yields (82-94 %), facile work-up, achieving high purity of products via simple recrystallization, and short reaction times (2-5 min) are some advantages of this procedure. It is worth noting, the catalyst is magnetically removed without significant loss of activity for reuse a few times.
Graphical AbstractNiFe 2 O 4 MNPs(10 mol %)
Reactions of benzoic acid derivatives and (E)-cinnamic acid derivatives with N, N-dialkyl carbodiimide proceed smoothly at room temperature and in neutral conditions to afford N-acylurea derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.
Tetramethylguanidine-functionalized silica-coated iron oxide magnetic nanoparticles as a productive and reusable catalyst have been applied for the one-pot three-component synthesis of furanone derivatives (4a-o). In addition to the characterization of all products by FT-IR, 1 HNMR and 13 CNMR spectroscopy, single-crystal X-ray analysis of ethyl 5-oxo-2-phenyl-4-(phenylamino)-2,5-dihydrofuran-3carboxylate product has been made. Easy recrystallization and good-to-excellent yields (81-92%) of furanone derivatives are notable characteristics of this procedure. The catalyst identification was performed using FT-IR, XRD, SEM, TEM and TGA techniques. It is worth noting that the nanocatalyst can be recycled with an external magnet and reused for several times.
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