Summary: Different lignins were converted into polyols by a chain extension reaction with propylene oxide (PO). Thus, soda lignin from Alfa (Stipa tenacissima) (SL), organosolv lignin from hardwoods (OL), kraft lignin (KL) from softwood and oxidized organosolv lignin (OOL) were oxypropylated in a batch reactor at 180 °C in the presence of KOH as catalyst. The ensuing polyols were characterized by FTIR and 1H NMR spectroscopy, which showed that they had incorporated poly(propylene oxide) grafts into their structure. Their viscosity varied from 5 mPa · s to infinity, depending on the Lignin/PO ratio and their hydroxy index was in the range of 100–200, which made them suitable for rigid polyurethane foam (RPU) formulations. The RPUs thus obtained had a Tg of ca. 60 °C and a thermal conductivity of ≈20 mW/m · K before ageing and ≈25 mW/m · K after accelerated ageing for 10 d at 70 °C. The analyses of the gases inside the cells showed that these were mostly closed, since the partial pressure did not decrease significantly with ageing.

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Attention deficit hyperactivity disorder (ADHD) is the most common behavioral disorder in childhood, and often has effects detectable into adulthood. Advances in genetic linkage and association analysis have begun to elucidate some of the genetic factors underlying this complex disorder. Recently, we identified LPHN3, a novel ADHD susceptibility gene harbored in 4q, and showed that a LPHN3 common haplotype confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Here we present the mutational analysis of the entire coding region of LPHN3 in a cohort of 139 ADHD subjects and 52 controls from across the USA. We identified 21 variants, of which 14 have been reported and 7 are novel. These include 5 missense, 8 synonymous, and 8 intronic changes. Interestingly, neither susceptibility nor protective haplotype alleles are associated with obviously significant coding region changes, or canonical splice site alterations, suggesting that non‐coding variations determining the quantity and/or quality of LPHN3 isoforms are the likely contributors to this common behavioral disorder. © 2010 Wiley‐Liss, Inc.