In the present study Hemostatic effects of Surgicel Snow and Surgicel Fibrillar in 12 cases in dogs were observed. The dogs were divided into three groups via group A, B and C with four dogs in each group. All three groups were anesthetized by the combination of xylazine (1.1mg/kg) and ketamine (5.5mg/kg) administered intravenous. Group A received Surgical Gauze, Surgicel Snow was employed in Group B and Surgicel Fibrillar was used in Group C. Hemostasis time, Liver function test (LFT), Complete blood count (CBC), Temperature, Pulse rate and Respiratory rate (TPR), Ultrasonography were evaluated. Hemostasis time was significantly less in animals who had received a Surgicel Snow compared to Surgicel Fibrillar and Surgical Gauze. LFT values were significantly different among all three groups. CBC values also differ among all groups. In TPR there were no significant differences in all groups. All groups showed no changes during Ultrasonography of liver. Surgicel Snow is better hemostat than Surgicel Fibrillar with minimum blood loss and least effects on liver function.
Objective: The aim of this study was to access clinical presentation of chronic subdural hematoma and to evaluate the surgical outcome of evacuation of chronic subdural hematoma after single burrhole craniotomy with a close drainage system under local anesthesia.
Material & Methods: A descriptive study conducted in the Neurosurgery Department of Khairpur Medical College Sindh. 30 patients of chronic subdural hematoma were included. Patients prepared for evacuation of chronic subdural hematoma through single burr hole followed by closed drainage system for two days.
Results: The most common feature was gait disturbance followed by Hemiparesis and headache. Coexisting diseases were hypertension, Diabetes mellitus and Chronic Liver Disease, etc. and causes of CSDH were head injury (trivial trauma) and anticoagulant. Surgical decisions were taken on the bases of clinical presentation and radiological findings of patients. Surgical procedure single burrhole craniotomy followed by irrigation with normal saline and close drainage system for two days. On post-operative follow-up, a recurrence of CSDH occurred in two patients.
Conclusion: Single burrhole craniotomy with close drainage system is a simple and safe procedure under local anesthesia for treatment of chronic subdural hematoma.
Keywords: CSDH (chronic subdural hematoma), GCS (Glasgow coma score), Burrhole craniotomy, Neurosurgery & Subdural drain.
B ACKGROUND: Cutaneous wound healing in equine is frequently delayed and complicated. Therefore, a new therapy is needed to achieve rapid and satisfactory healing. Aims: This study aimed to investigate whether the use of autologous PRP gel in cutaneous wounds enhances wound repair and alters oxidative stress cascades than homologous PRP-gel in the rescued donkeys. Methods: 10 rescued donkeys were selected and allocated into two groups A and B. Group-A donkeys (n=5) were treated with APRP-gel, while group-B donkeys (n=5) were treated with HPRP-gel. A full-thickness (4 mm 2 ) skin wounds were selected in each donkey. Wound re-epithelialization was assessed by H&E staining and collagen reestablishment was assessed by Masson's trichrome staining. The CAT activity and MDA concentration were assessed in blood samples on days 7, 21, and 36. Results: We observed a significant increase in re-epithelialization, fibroblasts and angiogenesis from days 21 (P < 0.05) to 36 (P < 0.01) in APRP-wounds than HPRP-wounds. Collagen organization in APRPwounds was good (P<0.05) from days 21 to 36 than HPRP-wounds. Malondialdehyde (MDA) concentrations in APRP-wounds were significantly decreased from day 21 to day 36 compared with HPRP-wounds (P<0.01). There was no difference in catalase (CAT) activity between APRP and HPRP wounds (P>0.05). Conclusion: APRP-wounds improved cutaneous wound healing in rescued donkeys by reducing oxidative stress, speeding wound epithelialization, and developing more structured tissue with interlocking collagen bundles than HPRP wounds. However, further ultrasonography study is required to investigate the effect of PRP gel on cutaneous wound healing in rescued donkeys.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.