In present scenario, light weighting becomes a main issue for energy efficiency in automotive industry. The emission of gases and fuel efficiency of vehicles are two important issues. The best way to improve the fuel efficiency is to decrease the weight of vehicle parts. Research and development played an important role in lightweight materials for decreasing cost, increasing ability to be recycled, enabling their integration into vehicles, and maximizing their fuel economy efficacy. There arises a need for developing a novel generation of materials that will combine both weight reduction and safety issues. The application of carbon fibre reinforced plastic material offers the best lightweight potential to realize lightweight concepts. Carbon fibre reinforced plastic has outstanding specific stiffness, specific strength, and fatigue properties compared to commonly used metals. In automotive industry, the advantages of carbon fibre reinforced plastic are reduction in weight, part integration and reduction, crashworthiness, durability, toughness, and aesthetic appealing. Carbon fibre reinforced plastic is a composite material that has been used extensively in various applications such as aerospace industry, sports equipment, oil and gas industry, and automotive industry. Keeping in view the aforementioned advantages of carbon fibre reinforced plastic, the authors have presented a brief review on carbon fibre for automotive industrial applications.

Dendritic spines compartmentalize information in the brain, and their morphological characteristics are thought to underly synaptic plasticity. Here we identify copine-6 as a novel modulator of dendritic spine morphology. We found that brain-derived neurotrophic factor (BDNF) - a molecule essential for long-term potentiation of synaptic strength - upregulated and recruited copine-6 to dendritic spines in hippocampal neurons. Overexpression of copine-6 increased mushroom spine number and decreased filopodia number, while copine-6 knockdown had the opposite effect and dramatically increased the number of filopodia, which lacked PSD95. Functionally, manipulation of post-synaptic copine-6 levels affected miniature excitatory post-synaptic current (mEPSC) kinetics and evoked synaptic vesicle recycling in contacting boutons, and post-synaptic knockdown of copine-6 reduced hippocampal LTP and increased LTD. Mechanistically, copine-6 promotes BDNF-TrkB signaling and recycling of activated TrkB receptors back to the plasma membrane surface, and is necessary for BDNF-induced increases in mushroom spines in hippocampal neurons. Thus copine-6 regulates BDNF-dependent changes in dendritic spine morphology to promote synaptic plasticity.

This study uses a structural model to analyze the co-determinants of capital structure and stock returns. Applying a generalized method of moments (GMM) model to a panel dataset for 100 nonfinancial firms for the period 2006– 10, our results indicate that both leverage and stock returns affect each other but that the former has a dominant effect on the latter. The results illustrate that profitability, growth, and liquidity are significant determinants of leverage and stock returns. Profitability negatively affects leverage and positively affects stock returns. Growth has a positive effect, while liquidity has a negative effect on leverage and stock returns. Firm size does not have any significant effect on either capital structure or stock returns.

Objective: The objective of this study was to identify the outcomes of short term inspiratory muscle training (IMT) combined with chest physiotherapy (CP) on lung function, inspiratory muscle strength, exercise tolerance and quality of life of COPD patients. Materials and Methods: This randomized-controlled trial was conducted at the Terendak Armed Forces Hospital, Melaka. Eighteen hospitalized COPD patients (FEV1 50% to = 80% predicted) were randomized into intervention (IG) and control group (CG). The IG received IMT and CP treatments whilst the CG received only CP for a period of 4 weeks. Assessments of lung function (FEV1/FVC), inspiratory muscle strength (PImax), exercise tolerance (6MWT) and quality of life (SGRQ score) were taken at baseline and after 4 weeks. Results: Analysis showed IG group increased in FEV1/FVC by 19.4%, PImax by 54.7%, 6MWT by 33.2% and quality of life by 52.6% (All, p<0.05). The control group increased in FEV1/FVC by 8.7% (p>0.05), PImax by 15% (p<0.05), 6MWT by 18.9% (p<0.05) and quality of life by 15.6% (p<0.05). Conclusion: The present study has established that by combining inspiratory muscle training (IMT) and chest physiotherapy, provides superior effects on lung function, inspiratory muscle strength, exercise tolerance and quality of life among COPD patients. DOI: http://dx.doi.org/10.3329/bjms.v12i4.13302 Bangladesh Journal of Medical Science Vol. 12 No. 04 October ’13 Page 398-404

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Pulping is one important step in wet coffee processing method. Pulping process usually uses a machine which constructed by wood or metal materials. A horizontal single cylinder type of fresh coffee cherries pulping machine is the most popular machine in coffee processing. One of the weaknesses of a horizontal single cylinder type of fresh coffee cherries pulping machine is higher in broken beans. Broken bean is one of mayor aspects in defect system that contribute to low quality. Indonesian Coffee and Cocoa Research Institute has designed and tested a horizontal double cylinder type of fresh coffee cherries pulping machine which resulted in 12.6—21.4% of broken beans. To reduce percentage of broken beans, Indonesian Coffee and Cocoa Research Institute has developed and tested a horizontal triple cylinder type of fresh coffee cherries pulping machine. Material tested was fresh mature Robusta coffee cherries, 60—65% (wet basis) moisture content; has classified on 3 levels i.e. unsorted, small and medium, and clean from metal and foreign materials. The result showed that the machine produced 6,340 kg/h in optimal capacity for operational conditions, 1400 rpm rotor rotation speed for unsorted coffee cherries with composition 55.5% whole parchment coffee, 3.66% broken beans, and 1% beans in wet skin.Key words : coffee, pulp, pulper, cylinder, quality.

Data is about the mitochondrial apoptosis regulatory framework genes PUMA, DRP1 (apoptotic), and ARC (anti-apoptotic) analysis after the employment of their controlling miRNAs inhibitors. The data represents putative conserved targeting of seed regions of miR-15a, miR-29a, and miR-214 with respective target genes PUMA, DRP1, and ARC. Data is of cross interference in expression levels of one miRNA family, miR-29a and its putative target DRP1 upon the inhibitory treatment of other miRNAs 15a and 214.