“…17 Meanwhile, in the valves of the CKD rat model, miR-29a was found to be decreased compared to CTL, which was consistent with previous studies in non-CKD VC diseases. [26][27][28] Besides, the miR-29a/b cluster was reported to suppress high glucose-induced EndMT in human retinal microvascular endothelial cells. 29 In this study, overexpression of miR-29a was shown to inhibit PTH-induced EndMT in the valves of CKD rats.…”
Valvular calcification (VC), a common complication of chronic kidney disease (CKD), is more prevalent in CKD patients than in normal individuals, which mostly occurs in the aortic and mitral valves. 1 The morbidity of VC among patients on dialysis is 28%-50%, 2 which severely affects the survival rate and living quality of CKD patients. Among patients undergoing long-term dialysis, the number of calcified valves has previously been shown to be associated with all-cause mortality and cardiovascular death. Accordingly, 1-year all-cause
“…17 Meanwhile, in the valves of the CKD rat model, miR-29a was found to be decreased compared to CTL, which was consistent with previous studies in non-CKD VC diseases. [26][27][28] Besides, the miR-29a/b cluster was reported to suppress high glucose-induced EndMT in human retinal microvascular endothelial cells. 29 In this study, overexpression of miR-29a was shown to inhibit PTH-induced EndMT in the valves of CKD rats.…”
Valvular calcification (VC), a common complication of chronic kidney disease (CKD), is more prevalent in CKD patients than in normal individuals, which mostly occurs in the aortic and mitral valves. 1 The morbidity of VC among patients on dialysis is 28%-50%, 2 which severely affects the survival rate and living quality of CKD patients. Among patients undergoing long-term dialysis, the number of calcified valves has previously been shown to be associated with all-cause mortality and cardiovascular death. Accordingly, 1-year all-cause
“…miR-214 is expressed widely in various tissues and cells, targeting a variety of genes involved in cancer development, the immune system, differentiation of skeletal muscle cells, protection of the heart from ischemic injury, and inhibition of angiogenesis 41, 42, 43, 44. Recently, it has received heightened interest, as it may function as both a diagnostic marker and therapeutic target for bone disease.…”
Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse of the femoral head, is characterized by increased osteoclast activity and markedly decreased osteoblast activity in the necrotic region of the femoral head. MicroRNA (miRNA)-214 (miR-214) may play important roles in vertebrate skeletal development by inhibiting osteoblast function by targeting activating transcription factor 4 (ATF4) and promoting osteoclast function via phosphatase and tensin homolog (PTEN). This study revealed significantly increased levels of miR-214 in necrotic regions, with commensurate changes in the numbers of its target cells (both osteoblasts and osteoclasts). To investigate whether targeting miR-214 could prevent femoral head collapse, we constructed an adeno-associated virus (AAV)-associated anti-miR-214 (AAV-anti-miR-214) and evaluated its function in vivo. AAV-anti-miR-214 promoted osteoblast activity and diminished osteoclast activity, effectively preventing collapse of the femoral head in a rat model of osteonecrosis.
“…Regulation of Mitochondrial pathology associated genes may be of great merit for multiple disorders with damaged mitochondria as cardiac diseases, cancers and kidney diseases [1] . Present data is about the miRNAs regulation of mitochondrial apoptosis regulatory framework genes PUMA, DRP1 (apoptotic) and ARC (anti-apoptotic).…”
Section: Datamentioning
confidence: 99%
“…The data presented here showed non significant alteration at expression level and this does not imply that specific miRNA inhibitor strongly attenuates the other miRNAs and respective targets. Our recent studies showed that miR-15a and miR-214 inhibitors treatment leads to significant inhibition of their target miRNAs and enhanced the expression of respective genes PUMA and ARC by many folds [1] . Fig.…”
Data is about the mitochondrial apoptosis regulatory framework genes PUMA, DRP1 (apoptotic), and ARC (anti-apoptotic) analysis after the employment of their controlling miRNAs inhibitors. The data represents putative conserved targeting of seed regions of miR-15a, miR-29a, and miR-214 with respective target genes PUMA, DRP1, and ARC. Data is of cross interference in expression levels of one miRNA family, miR-29a and its putative target DRP1 upon the inhibitory treatment of other miRNAs 15a and 214.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
