Background: Advanced age is associated with changes in the pituitary thyroid axis which lead to changes in the thyroid functions in the absence of thyroid diseases. There is limited data regarding the prevalence of thyroid disease in the elderly Egyptian. It is very important to evaluate the thyroid function in the elderly people. Methods: 126 asymptomatic volunteers (41 males & 85 females) were initially interviewed and examined, and those fulfilling the clinical inclusion criteria were selected. Serum samples were taken and free T3, free T4 and TSH were measured. Results: Our study showed that the thyroid function abnormalities were present in 20 subjects (15.9%). The prevalence rates of thyroid function abnormalities occurred in 8 males (19.5%) and 12 females (14.1%). Subclinical hypothyroidism was the most common thyroid dysfunction which occurred in in 11 subjects (8.7%) 8 females, with prevalence rate of 9.4% in the females and in 3 males with prevalence rate of 7.3%. Subclinical hyperthyroidism was the second most common thyroid abnormality which occurred in 5 subjects (4%) with 7.3% in males (3 males)) and 2.4% in females (2 females). The prevalence rate of clinical hypothyroidism was (1.6%) (2 females) and in males 0%., and of clinical hyperthyroidism was (1.6%) 2 males and no female. According to the age group, thyroid dysfunction as general occurred in 20 subjects (23.5%) in those people < 70 years, and (0%) in those ≥ 70 years, with significant p-value < 0.05.Conclusions: Thyroid dysfunction is common in elderly subjects.
Background: The 15kDa cytoplasmic fatty acid-binding protein family (FABPs) is one of the most exciting novel indicators for the diagnosis of renal damage. Objective: The aim of this study was to investigate the relation of circulating FABP1 and FABP2 levels as clinical and biochemical markers and varying stages of nephropathy in senior T2DM patients. Patients and Methods: This case-control study included a total of 60 patients with Type 2 diabetes and 30 nondiabetic controls, attending and followed up at Out-
Background: The prevalence of diabetes among hospitalized patients is high. One out of 4 hospitalized patients has diabetes; thus, treating hyper-or hypoglycemia represents an everyday challenge in hospitals worldwide. Objective: This study aimed to assess the level of adherence to current American practice guidelines for inpatient pharmacologic management of type 2 diabetes and its effect on glycemic outcomes. Patients and Methods: A prospective study was conducted in Internal Medicine Department, Faculty of Medicine, Zagazig University in the period from April 2020 to April 2021. It included 50 patients with type 2 diabetes who were treated with insulin and/or other antihyperglycemic drugs. They were followed up during their hospital stay for hyperglycemic and hypoglycemic episodes. Results: Mean capillary blood glucose measurement (CBGM) throughout three days were higher among Guideline adherence group than Guideline non-adherence group (12.6±1.04 vs. 5.2±1.3) with statistically significant difference p<0.0001. In addition, 88.0% of Guideline adherence group CBGM was measured four times or more per day. The incidence of hyperglycemic reading (12.0% in Guideline adherence group and 36.0% in Guideline non-adherence group) showed statistically significant difference p= 0.047. Conclusions: There is a good level of adherence to the current American guidelines for inpatient management of type 2 diabetes. The level of adherence is greater with more training and clinical seniority.
Background: Frailty recognized as a common clinical syndrome associated wih a high rate of morbidity and mortality. Aim of the Study: This study aimed at assessing the value of determination of some biomarkers in identification and recruitment of frail elderly. The association between these biomarkers and stages of frailty were also assessed Subjects and Methods : A total number of 100 elderly subjects (above 65 years old) were included in the work divided into three groups : Group 1 (non-frail) included 34 subjects (19 males and 15 females), their ages ranged from 66.3 to 72.9 with mean 67.6 + 3.3 year; Group 2 (pre-frail) included 26 subjects (1 males and 15 females), their ages ranged from 65.5 to 73.1 with mean age of 69.3 + 3.8 year and Group 3 (frail) included 40 subjects (25 males and 15 females), their ages ranged from 67.9+ to 78.3 with mean age of 73.1+5.2 year.All subjects of this study were subjected to : thorough clinical examination, Anthropometric measures (including mid upper arm circumference, mid calf circumference, body mass index), Timed get-up-and-go test, hand grip strengh test and laboratory investigations (including complete blood picture, serum albumin, serum alanine transferase, INR. Prothrombin time and partial thromboplastin time, Cholesterol and C-reactive protein.Results: In our study; frailty recorded higher prevalence than most of epidemiological studies. Regarding CRP, there was significant increase in CRP level in frail group (27.4 + 8.1 mg/l) compared to both pre-frail (14.3 + 4.5 pg/ml) and non-frail groups (7.5 + 5.5 pg/ml). Regarding cholesterol, there was significant decrease in cholesterol level in frail group (125.7 + 54.9) compared to both pre-frail (168.1 + 17.2) and non-frail (165.3 + 29.7) groups. Regarding TGUGT, it was prolonged in frail group compared to both pre-frail and non-frail groups. Conclusions: There is high prevalence of frailty among studied elderly population, the causes of which need further studies to unravel. The changes in biomarkers noticed in our frail elderly may suggest its use in diagnosis and follow up of frailty, a suggestion that still in its infancy and needs further more studies to verify.
Background: Frailty recognized as a common clinical syndrome associated wih a high rate of morbidity and mortality. Aim of the Study: This study aimed at assessing the value of determination of some biomarkers in identification and recruitment of frail elderly. The association between these biomarkers and stages of frailty were also assessed Subjects and Methods : A total number of 100 elderly subjects (above 65 years old) were included in the work divided into three groups : Group 1 (non-frail) included 34 subjects (19 males and 15 females), their ages ranged from 66.3 to 72.9 with mean 67.6 + 3.3 year; Group 2 (pre-frail) included 26 subjects (1 males and 15 females), their ages ranged from 65.5 to 73.1 with mean age of 69.3 + 3.8 year and Group 3 (frail) included 40 subjects (25 males and 15 females), their ages ranged from 67.9+ to 78.3 with mean age of 73.1+5.2 year.All subjects of this study were subjected to : thorough clinical examination, Anthropometric measures (including mid upper arm circumference, mid calf circumference, body mass index), Timed get-up-and-go test, hand grip strengh test and laboratory investigations (including complete blood picture, serum albumin, serum alanine transferase, INR. Prothrombin time and partial thromboplastin time, Cholesterol and C-reactive protein.Results: In our study; frailty recorded higher prevalence than most of epidemiological studies. Regarding CRP, there was significant increase in CRP level in frail group (27.4 + 8.1 mg/l) compared to both pre-frail (14.3 + 4.5 pg/ml) and non-frail groups (7.5 + 5.5 pg/ml). Regarding cholesterol, there was significant decrease in cholesterol level in frail group (125.7 + 54.9) compared to both pre-frail (168.1 + 17.2) and non-frail (165.3 + 29.7) groups. Regarding TGUGT, it was prolonged in frail group compared to both pre-frail and non-frail groups. Conclusions: There is high prevalence of frailty among studied elderly population, the causes of which need further studies to unravel. The changes in biomarkers noticed in our frail elderly may suggest its use in diagnosis and follow up of frailty, a suggestion that still in its infancy and needs further more studies to verify.
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