Aim: To evaluate the therapeutic effectiveness of the use of photodynamic therapy in chronic traumatic lesions of oral mucosa. Materials and methods: Clinical examination and treatment of 67 patients aged 18-65 years with erosive-ulcerative lesions of oral mucosa were carried out. Treatment of patients in the main group was performed using photodynamic therapy. Treatment of patients of the control group was carried out according to the standard method. The results of treatment were evaluated by clinical and cytological parameters. Results: In all patients of the main group with chronic traumatic erythema, already on the second day of treatment, complaints of pain when talking and eating completely disappeared, and on the third day in 100% of patients the affected mucosa had no pathological changes. In patients with erosive-ulcerative lesions, complete clinical recovery in the main group was observed on the 3-4th day of treatment, in the control group – on the 7-10th day. The results of cytological examination, namely the absence of young epithelial cells of stages 1 and 2 of differentiation, a significant decrease of intermediate maturity cells (stages 3 and 4) and a similar increase of mature cells (stages 5 and 6), indicated the acceleration of mucosal regeneration in patients of the main group compared to the control group. Conclusions: The use of photodynamic therapy in the treatment of traumatic oral mucosa lesions contributed to the acceleration of elimination of clinical manifestations of chronic mechanical injuries and the normalization of parameters of cytological characteristics of epithelial cells in patients of the main group compared to the group of standard treatment.
Annotation. The study aimed to analyze references in the scientific literature on hard dental tissue damage and periodontal and oral mucosal diseases in patients with concomitant gastrointestinal tract pathology. We used the bibliosemantic method to identify the status of the outlined issues and analysis of the scientific research data. Based on data from national and international published literature on the topic, the prevalence, severity and structurality of changes in the organs and tissues of the oral cavity associated with gastrointestinal tract diseases were evaluated. The review was carried out using data from scientific articles for the period of 2011-2022 with search words “Digestive System Diseases”, and “Diseases of the Oral Cavity” using the MESH subject headings: dental caries susceptibility, mouth diseases, gastrointestinal diseases, malabsorption syndromes, dental caries, tooth demineralization and others. The final analysis included 75 scientific articles corresponding to the purpose of the study. Data obtained from analysis of literary sources of recent years suggests that both local and general factors are involved in the process of occurrence and course of dental pathology with concomitant involvement of the gastrointestinal tract. The nature of their interaction will determine the peculiarities of the course of dental diseases. However, the lack of convincing data on the age-related features of the occurrence and development of dental diseases, as well as the inconsistency of the results regarding the significance of risk factors for the progress of comorbid conditions complicates the methods development of their treatment and prevention. The listed features of the course of dental diseases with a combined involvement of gastrointestinal disorders indicate the mandatory complexity of treatment, taking into account concomitant pathology.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.