Replacement of the damaged bone remains actual and is far from being completely solved nowadays, despite its centuries-old history. The purpose of study was to investigate the anti-inflammatory and osteo-regenerative qualities of the paste based on Symphytum officinale tincture and calcium hydroxide in treatment on teeth with chronic granulating apical periodontitis in children and in an experiment on animals. Performed morphological and densitometric studies showed that remodeling of bone injury of the lower jaw in rats occurs almost equally in both experimental and control groups, and a paste based on Symphytum officinale tincture and calcium hydroxide also promotes bone regeneration at the defect site and stimulates osteosynthesis. Analysis of liver tissue, soft and hard tissues of the lower jaw in animals suggest that the proposed paste does not produce any toxic effect and provides significant anti-inflammatory properties. The gained result provide grounds to recommend the developed paste for therapeutic use in children as a temporary root canal sealing material in permanent teeth with granulating apical periodontitis.
There were studied 92 somatically healthy persons of young age (18-25 years old), with generalized periodontitis (GP) of initial-I degree of development, among them: 30 patients with chronic generalized periodontitis (CGP), who were included into group I; and 32 patients with exacerbation of the chronic generalized periodontitis (ECGP) -into group II; and 30 healthy patients. The carbohydrate metabolism indexes were studied, namely: the content of glucose, pyruvate (pyruvic acid) and lactate (lactic acid) and lactate dehydrogenase activity (LDG) in the oral liquid. We have determined that in the presence of CGP of the initial-I degree of development, and especially in its exacerbation, there is a significant increase of indicators of carbohydrate metabolism. In young patients with CGP indicators of glucose, pyruvate, lactate and LDG activity in the oral liquid increased by 2.0, 1.34, 1.58 and 1.37 (p<0.001, p<0.01) times respectively, and in case of ECGP they grew even more: by 2.71, 1.98, 1.76 and 2.07 (p<0.001) times, respectively. Among all the indicators, that characterize the carbohydrate metabolism, in addition to the level of pyruvate, in case of different course of GP a significant difference was revealed: in patients with ECGP compared with the data in CGP, glucose and lactate levels and LDG activity in the oral liquid were significantly higher -at 35.75% (p<0.05), 34.29% (p<0.01) and 36.59% (p<0.001) respectively. Detected violations of carbohydrate metabolism indeces in the oral liquid indicate the involvement of these processes in the pathogenesis of GP and the necessity of their correction. Keywords generalized periodontitis; oral fluid; carbohydrate metabolismIvano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine *Corresponding author: alina.Kimak@gmail.com Problem statement and analysis of the recent researchDiseases of periodontal tissues, especially GP is one of the most topical problems of dentistry, which acquires a high social significance, caused by a considerable prevalence of the disease in young people and the possibility of development of severe changes in periodontal tissues and the body of the patient as a whole [1,7,13]. Having remission periods and exacerbation, the GP often significantly impairs the functions of the dentofacial system because of the bony tissue resorption and damage of the retaining apparatus of the teeth [3].The most recent data on the problems of etiopathogenesis of GP suggest that besides morpho-functional disorders of the tooth-jaw system, there is a number of violations in the metabolic status of the patient's body, in particular, protein and carbohydrate metabolism [8,11]. In this case, the metabolism of carbohydrates in patients with GP, especially in young people, was barely studied. In this regard, the study of the state of carbohydrate metabolism in patients with GP is relevant.The objective of the research is to study the parameters of carbohydrate metabolism in the mouth fluid of young people with GP of initial-I degree of developm...
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