A series of azo-azomethine compounds (Sb1- Sb5) have been synthesized with magnificent yield by condensation reaction of 4-((3-formyl-4-hydroxy-5-methoxyphenyl)diazenyl) enzenesulfonamide and aniline derivatives. The new azo compound was prepared from sulfanilamide by converting it to diazonium salt followed by coupling reaction with 2-hydroxy-3-methoxybenzaldehyde in alkaline medium. The structures of synthesized azo and azo-azomethine compounds have been established based on their spectral data (FT-IR,1HNMR,13CNMR)and elemental analysis (C,H,N).The purity of compound and evaluation of Rf value were determined by TLC. The antimicrobial activity of azo-azomethine compounds have been tested in vitro against bacteria (Staphylococcus aureus, Escherichia coli and Klepsilia pneumonia) and fungi (Candida glabrata, Candida albicane and Aspergillus niger) by agar diffusion method, to assess their inhibiting potential. Also the antioxidant efficiency of azo-azomethine compounds have been calculated.
About 12,000 chemical compounds isolated from medicinal plants and used to conduct crucial biological functions. These phytochemicals offer long-term health benefits for humans, thus they can be used effectively for treat a variety of human ailments. The goal of this study was to assess the in vitro free radical scavenging and antibacterial activities of glycoside, flavonoid and alkaloid extracts of Tilia cordata plant. According to the findings, flavonoid extract exhibits strong inhibitory action against Staphylococcus aureus but no activity against Escherichia coli. The free radical scavenging activity exhibited that the flavonoid extract was more effective in inhibiting lipid peroxidation more than alkaloid extract, whereas the glycoside extract had no antioxidant activity.
Herpes are a group of similar viruses that are responsible for a number of infecting diseases, the most important of which are herpes simplex, herpes zoster and pseudopox. Resistance to traditional antiviral medications is becoming increasingly common, making treatment of such infections even more difficult. For example, the usage of nucleoside analogues like acyclovir to target the DNA-polymerase of the virus on a regular and long-term basis promotes the generation of resistant viruses. As a result, a different treatment is required. Natural products, such as herbal remedies, have been shown to have in vitro and in vivo activity against herpes viruses, and have shown to be a valuable source for new antivirals development and separation. The goal of this review is to highlight the most promising extracts and pure chemicals obtained from plants and marine species that have in vivo anti-herpes simplex virus (HSV-1 and HSV-2) action. Natural products as new anti-HSV medications offer a number of benefits, including fewer side effects, minimal toxicity, and lowered resistance, and a variety ways of deed.
Biodegradation is utilizing microorganisms to degrade materials into products that are safe for the environment, such as carbon dioxide, water, and biomass. The current study aims to isolate and characterize bacteria with polyethylene terephthalate (PET) degradation ability isolated from Shatt al-Arab water and sewage from Basra, the bacteria were identified as Klebsiella pneumonia. According to the findings, the isolates showed a highly significant difference in degradation of PET (24% during 7 days) and the percent of degradation increased to 46% at 4 weeks compared to the control. The study also involved determining the optimum temperature of K. pneumonia growth, which was 37°C, while the preferred pH was 7-8. The research revealed that PET biodegradation by K. pneumonia can be used as a suitable and environmentally friendly tool.
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