Aim of the Work: Study the role of muscular exercise in modulating the progress of peptic ulcer treated by quercetin or dexilant in rats. Methods: 80 male rats divided into 8 equal groups: Control, gastric ulcer non-treated, gastric ulcer with exercise, dexilant treated gastric ulcer, quercetin treated gastric ulcer, dexilant treated gastric ulcer with exercise, quercetin treated gastric ulcer with exercise, quercetin and dexilant treated gastric ulcer groups. At the end, the collected samples were used to analyze PH, total gastric acidity, ulcer index(UI), curative index(CI), heat shock protein 70(HSP70), asymmetric dimethyle arginine(ADMA), tumor necrotic factor alpha(TNFα) levels. Histopathological and immunohistochemical analyses were done. Results: Non-treated group showed significant decrease of gastric levels of pH and CI with significant increase of gastric total acidity, UI, HSP70, ADMA and TNFα. Also, deterioration of histopathological and immunohistochemical expression of Bcl-2 with increase of NF-κB immunohistochemical expression compared to control group.
Introduction: Alzheimer's disease (AD) is a progressive neurological disorder. Donepezil hydrochloride is a cholinesterase inhibitor that is selective. Irisin is a 112-amino acid glycosylated protein-hormone. Objective: to compare the effect of irisin and donepezil (anticholinestrase) on cognitive function in cases of scopolamine induced Alzheimer’s disease like condition in male albino rats. Materials and methods: Fifty albino male rats of a local strain, weighing between 150 and 200 g, enrolled in this study. At room temperature, with 12-hour light/dark cycles, and with free access to running tap water and pelleted laboratory chow, the rats were kept in separate cages (5 rats per cage) for the duration of the experiment. Results: Donepezil administration achieved significant decrease in A che level in donepezil treated group, in relation to AD group, (AD+D). Irisin administration caused insignificant change in A che level in Irisin treated group in relation to AD group (AD+I). Conclusions: Irisin can reduce scopolamine-induced AD manifestations through its antiinflammatory, antioxidant and antiapoptotic effects, which were evaluated both biochemically and behavioural. Donepezil enhances memory as it is anti cholinestrase, also it has anti-inflammatory effect. Donepezil and irisin treatment potentiate each other as they act synergestically by different mechanisms to counrtact memory loss.
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