Evaluating the role of muscular exercise in modulating the progress of peptic ulcer treated by quercetin or dexilant in male albino rats

Abstract

Aim of the Work: Study the role of muscular exercise in modulating the progress of peptic ulcer treated by quercetin or dexilant in rats. Methods: 80 male rats divided into 8 equal groups: Control, gastric ulcer non-treated, gastric ulcer with exercise, dexilant treated gastric ulcer, quercetin treated gastric ulcer, dexilant treated gastric ulcer with exercise, quercetin treated gastric ulcer with exercise, quercetin and dexilant treated gastric ulcer groups. At the end, the collected samples were used to analyze PH, total gastric acidity, ulcer index(UI), curative index(CI), heat shock protein 70(HSP70), asymmetric dimethyle arginine(ADMA), tumor necrotic factor alpha(TNFα) levels. Histopathological and immunohistochemical analyses were done. Results: Non-treated group showed significant decrease of gastric levels of pH and CI with significant increase of gastric total acidity, UI, HSP70, ADMA and TNFα. Also, deterioration of histopathological and immunohistochemical expression of Bcl-2 with increase of NF-κB immunohistochemical expression compared to control group.