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of read mapping processes of reads with different properties and degrees of genetic variation, we meticulously design low-cost hardware accelerators and data/computation flows inside a NAND flashbased solid-state drive (SSD). Our evaluation using a wide range of real genomic datasets shows that GenStore, when implemented in three modern NAND flash-based SSDs, significantly improves the read mapping performance of state-of-the-art software (hardware) baselines by 2.07-6.05× (1.52-3.32×) for read sets with high similarity to the reference genome and 1.45-33.63× (2.70-19.2×) for read sets with low similarity to the reference genome. CCS CONCEPTS• Computer systems organization → Special purpose systems;• Hardware → External storage.

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