Electrochemical reduction of oxygen molecules can produce H2O2, which is an important chemical for a green and sustainable society; therefore, the development of catalysts for this reaction is necessary. We propose mesoporous nitrogen-doped carbon prepared from (1-methyl-1H-pyrrole-2-yl)­methanol in the presence of a mesoporous SiO2 template (KIT-6). The nitrogen content of the resulting carbon can be controlled in the range of 0–10 at. % and all prepared samples have well-ordered mesopores with diameters of 3.4–4.0 nm. Electrochemical studies indicate the present materials have high catalytic activities with high selectivity toward H2O2 over 90%. Such high selectivity toward H2O2 is probably due to good mass transport in the catalyst layer, which is enhanced by the mesoporous structure.

Epitaxial La-doped BaSnO 3 films were grown in an adsorption-controlled regime by molecular-beam epitaxy, where the excess volatile SnO x desorbs from the film surface. A film grown on a (001) DyScO 3 substrate exhibited a mobility of 183 cm 2 ·V -1 ·s -1 at room temperature and 400 cm 2 ·V -1 ·s -1 at 10 K, despite the high concentration (1.2×10 11 cm -2 ) of threading dislocations present. In comparison to other reports, we observe a much lower concentration of (BaO) 2 Ruddlesden-Popper crystallographic shear faults. This suggests that in addition to threading dislocations that other defects-possibly (BaO) 2 crystallographic shear defects or point defects-significantly reduce the electron mobility.

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator of diverse malignant properties of AML cells, direct targeting of STAT5 is of significant clinical value. Here, we describe the development and preclinical evaluation of a novel, potent STAT5 SH2 domain inhibitor, AC-4–130, which can efficiently block pathological levels of STAT5 activity in AML. AC-4–130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. Notably, AC-4–130 substantially impaired the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo. Furthermore, AC-4–130 synergistically increased the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol. Overall, the synergistic effects of AC-4–130 with TK inhibitors (TKIs) as well as emerging treatment strategies provide new therapeutic opportunities for leukemia and potentially other cancers.

We demonstrate that heat inhibits learning and that school air conditioning may mitigate this effect. Student fixed effects models using students who retook the PSATs show that hotter school days in the years before the test was taken reduce scores, with extreme heat being particularly damaging. Weekend and summer temperatures have little impact, suggesting heat directly disrupts learning time. New nationwide, school-level measures of air conditioning penetration suggest patterns consistent with such infrastructure largely offsetting heat’s effects. Without air conditioning, a 1°F hotter school year reduces that year’s learning by 1 percent. Hot school days disproportionately impact minority students, accounting for roughly 5 percent of the racial achievement gap. (JEL I21, I24, J15, Q54)

We demonstrate an all-perovskite transparent heterojunction field effect transistor made of two lattice-matched perovskite oxides: BaSnO3 and LaInO3. We have developed epitaxial LaInO3 as the gate oxide on top of BaSnO3, which were recently reported to possess high thermal stability and electron mobility when doped with La. We measured the dielectric properties of the epitaxial LaInO3 films, such as the band gap, dielectric constant, and the dielectric breakdown field. Using the LaInO3 as a gate dielectric and the La-doped BaSnO3 as a channel layer, we fabricated field effect device structure. The field effect mobility of such device was higher than 90 cm2 V−1 s−1, the on/off ratio was larger than 107, and the subthreshold swing was 0.65 V dec−1. We discuss the possible origins for such device performance and the future directions for further improvement.

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Results indicated that religious engagement and social support could be significant factors to improve the quality of life among elderly Korean immigrants. Social services that facilitate religiosity and social support may be beneficial for Korean elders' life satisfaction. Future studies are invited to replicate this study for diverse ethnic groups of elderly immigrants.

Putting a price on carbon is critical for climate change policy. Increasingly, policymakers combine multiple policy tools to achieve this, for example by complementing cap-and-trade schemes with a carbon tax, or with a feed-in tariff. Often, the motivation for doing so is to limit undesirable fluctuations in the carbon price, either from rising too high or falling too low. This paper reviews the implications for the carbon price of combining cap-and-trade with other policy instruments. We find that price intervention may not always have the desired effect. Simply adding a carbon tax to an existing cap-and-trade system reduces the carbon price in the market to such an extent that the overall price signal (tax plus carbon price) may remain unchanged. Generous feed-in tariffs or renewable energy obligations within a capped area have the same effect: they undermine the carbon price in the rest of the trading regime, likely increasing costs without reducing emissions. Policymakers wishing to support carbon prices should turn to hybrid instruments — that is, trading schemes with price-like features, such as an auction reserve price — to make sure their objectives are met.