Copper(II) and nickel(II) complexes of 2-formylpyridine 3-piperidinyl-, 3-hexamethyleneiminyt-and 3-azabicyclo-I-3.2.2]nonylthiosemicarbazones were prepared and characterized spectroscopically. 1H and ~3C n.m.r, spectra of the thiosemicarbazones and a diamagnetic nickel(II) complex are reported, together with i.r., electronic and e.s.r. spectra of the metal complexes. The thiosemicarbazones and their copper(II) and nickel(II) complexes exhibit considerable growth inhibitory activity against Paecilomyces variotii, but show minimal activity against Aspergillus niger.
Copper(II) complexes of a large number of 2-acetylpyridine 4N-alkylthiosemicarbazones were prepared and characterized. I.r., electronic and e.s.r, spectra of the complexes, as well as 1H and ~3C n.m.r, spectra of the thiosemicarbazones, were obtained. Both the thiosemicarbazones and their complexes show either modest or no growth inhibitory activity against Aspergillus niger, but many have considerable activity against Paecilomyces variotii. There is a relationship between the antifungal activity and size of the 4N-substituent for both the thiosemicarbazones and their copper(II) complexes.
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